公开(公告)号：US20170290773A1

公开(公告)日：2017-10-12

申请号：US15629087

申请日：2017-06-21

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education

发明人： Michael B. Chancellor ,  Pradeep Tyagi ,  Matthew O. Fraser ,  Yao-Chi Chuang ,  William C. de Groat ,  Leaf Huang ,  Naoki Yoshimura

IPC分类号： A61K9/127 ,  A61K9/00

CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K9/1272

摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysfunction.

公开(公告)号：US08771728B2

公开(公告)日：2014-07-08

申请号：US13712804

申请日：2012-12-12

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

IPC分类号： A61K9/127 ,  A61K38/00 ,  C07H21/04

CPC分类号： A61K47/48315 ,  A61K9/1272 ,  A61K47/543 ,  A61K47/645 ,  C12N15/88

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 所生成的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。