公开(公告)号：US20240199640A1

公开(公告)日：2024-06-20

申请号：US18550996

申请日：2022-03-18

Applicant: Vanderbilt University

Inventor： Craig W. Lindsley ,  P. Jeffrey Conn ,  Andrew S. Felts ,  Rory A. Capstick ,  David L. Whomble ,  Jeremy Coleman ,  Upendra Rathnayake ,  Daren Engers

IPC: C07D498/04 ,  A61K31/4035 ,  A61K31/4155 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/519 ,  A61K31/5365 ,  C07D209/46 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04

CPC classification number: C07D498/04 ,  A61K31/4035 ,  A61K31/4155 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/519 ,  A61K31/5365 ,  C07D209/46 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04

Abstract: Described are 6-aryl isoindolin-1-ones as negative allosteric modulators of metabotropic glutamate receptor 2 (mGlu2), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer's disease, or autism spectrum disorders in a subject.