Synthesis of arrays of oligonucleotides and other chain molecules
    1.
    发明申请
    Synthesis of arrays of oligonucleotides and other chain molecules 有权
    寡核苷酸和其他链分子阵列的合成

    公开(公告)号:US20070183943A1

    公开(公告)日:2007-08-09

    申请号:US11497544

    申请日:2006-08-01

    IPC分类号: B01J19/12 C12M3/00 C12Q1/68

    摘要: Synthesis of arrays of chain molecules, such as oligonucleotides, in large quantities can be carried out utilizing projection onto an active substrate of a magnified image of a light emitting object array having selectable regions of light and dark areas forming a pattern. Projection optics formed entirely of mirrors are used to receive the light emitted from the object array and image the pattern of the array onto the active surface of the substrate. The mirrors in the projection optics include a first, concave mirror, a second, convex mirror, a third, concave mirror, and a fourth, convex mirror, each receiving the beam of light in turn, with the light reflected from the fourth mirror being imaged onto the active surface of the substrate with an image area greater than that of the original light emitting array.

    摘要翻译: 可以通过投影到具有形成图案的光和暗区域的可选区域的发光物体阵列的放大图像的有源衬底上来进行大量的链分子例如寡核苷酸的阵列的合成。 完全由反射镜形成的投射光学器件用于接收从对象阵列发射的光并将阵列的图案成像到衬底的有源表面上。 投影光学元件中的反射镜包括第一凹面镜,第二凸面镜,第三凹面镜和第四凸面镜,每个反射镜依次接收光束,第四镜反射的光为 以比原始发光阵列大的图像面积成像到衬底的有源表面上。