公开(公告)号：US20240300878A1

公开(公告)日：2024-09-12

申请号：US18444075

申请日：2024-02-16

Applicant: WISys Technology Foundation, Inc.

Inventor： Ian Andrew MacKenzie ,  Mark Elliot Levenstein

IPC: C07C37/18 ,  B01J31/02 ,  B01J35/39 ,  C07D233/64 ,  C07D249/08 ,  C07D307/94 ,  C07F7/12

CPC classification number: C07C37/18 ,  B01J31/0201 ,  B01J31/0244 ,  B01J35/39 ,  C07D233/64 ,  C07D249/08 ,  C07D307/94 ,  C07F7/127 ,  B01J2231/4288

Abstract: Various embodiments disclosed relate to a method of preparing aryl fluorinated ether compounds. The method involves contacting an aryl halide with a fluorinated alcohol in the presence of a photocatalyst, a base, and irradiation with electromagnetic radiation comprising a wavelength between about 200 nm and about 800 nm. The present invention also provides a method of late-stage photochemical modification of a biologically active compound, such as drugs or agrochemicals. Fluorinated derivatives of griseofulvin, clofibrate, and 2,4-D methyl ester are described herein.