公开(公告)号：US20230033327A1

公开(公告)日：2023-02-02

申请号：US17896154

申请日：2022-08-26

申请人： Washington University

发明人： James W. JANETKA ,  Zhenfu HAN ,  Scott HULTGREN ,  Jerry PINKER ,  CORINNE CUSUMANO

IPC分类号： C07H15/203 ,  C07H15/26 ,  A61K31/7034 ,  A61K31/7042 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  A61K45/06

摘要： The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.

公开(公告)号：US20210347780A1

公开(公告)日：2021-11-11

申请号：US17277603

申请日：2019-09-19

申请人： Vyera Pharmaceuticals, LLC ,  Washington University

发明人： Allen T. HOPPER ,  L. David SIBLEY ,  James W. JANETKA

IPC分类号： C07D487/04

摘要： The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.