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20 条记录 (耗时 0.03 秒)

    Adaptation sphere saddle
    1.
    发明授权
    Adaptation sphere saddle 有权

    公开(公告)号：US09968378B1

    公开(公告)日：2018-05-15

    申请号：US15199053

    申请日：2016-06-30

    申请人： Wesley M. Johnson ,  Thomas B. Freeman

    发明人： Wesley M. Johnson ,  Thomas B. Freeman

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7037 ,  A61B17/7002 ,  A61B17/7032

    摘要： An improvement of a polyaxial screw head disclosed in the U.S. Pat. No. 8,277,490. A saddle resides within a tulip. The saddle is configured to mate with a rod. An outer set screw engages an inner surface of the tulip. An inner set screw is disposed within a lumen of an outer set screw. A force distributor has a concave surface configured to mate with the rod. The force distributor has a bore configured to accept a conical end of the inner set screw. The force distributor is configured to distribute the force applied onto the bore by the inner set screw along the contact area with rod. The force distributor allows the rod to pivot and have sagittal motion when the inner set screw is untightened. The force distributor immobilizes the rod within the saddle when the inner set screw is tightened.

    Translational manipulation polyaxial screw head
    7.
    发明授权
    Translational manipulation polyaxial screw head 有权
    平移式多轴螺丝头

    公开(公告)号：US08277490B2

    公开(公告)日：2012-10-02

    申请号：US12714953

    申请日：2010-03-01

    申请人： Thomas B. Freeman ,  Wesley M. Johnson

    发明人： Thomas B. Freeman ,  Wesley M. Johnson

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7037 ,  A61B17/704

    摘要： A novel surgical screw is presented as a polyaxial, multiaxial, or monoaxial screw. The polyaxial screw allows versatile angulation between a bone anchor section and a screw body and allows the surgeon to attach a rod to the invention in a top-loading manner and manipulate the rod to accommodate a patient's body and the surgical goals. The screw uses a rod saddle to seat a rod, and permits the surgeon to sagitally manipulate the rod. After implantation of the screw and insertion of the rod, a locking screw is used to fix the angle and position of the rod and screw body.

    摘要翻译： 一种新型外科手术螺钉被呈现为多轴，多轴或单轴螺钉。 多轴螺钉允许骨锚固部分和螺丝体之间的多角度成角度，并且允许外科医生以顶部装载方式将杆附接到本发明，并操纵杆以适应患者的身体和手术目标。 螺钉使用杆状鞍座来固定杆，并允许外科医生野蛮地操纵杆。 在植入螺钉和插入杆之后，使用锁定螺钉来固定杆和螺钉体的角度和位置。

    TRANSLATIONAL MANIPULATION POLYAXIAL SCREW HEAD
    8.
    发明申请
    TRANSLATIONAL MANIPULATION POLYAXIAL SCREW HEAD 有权
    翻译操作多轴螺丝头

    公开(公告)号：US20100234891A1

    公开(公告)日：2010-09-16

    申请号：US12714953

    申请日：2010-03-01

    申请人： Thomas B. Freeman ,  Wesley M. Johnson

    发明人： Thomas B. Freeman ,  Wesley M. Johnson

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7037 ,  A61B17/704

    摘要： A novel surgical screw is presented as a polyaxial, multiaxial, or monoaxial screw. The polyaxial screw allows versatile angulation between a bone anchor section and a screw body and allows the surgeon to attach a rod to the invention in a top-loading manner and manipulate the rod to accommodate a patient's body and the surgical goals. The screw uses a rod saddle to seat a rod, and permits the surgeon to sagitally manipulate the rod. After implantation of the screw and insertion of the rod, a locking screw is used to fix the angle and position of the rod and screw body.

    摘要翻译： 一种新型外科手术螺钉被呈现为多轴，多轴或单轴螺钉。 多轴螺钉允许骨锚固部分和螺丝体之间的多角度成角度，并且允许外科医生以顶部装载方式将杆附接到本发明，并操纵杆以适应患者的身体和手术目标。 螺钉使用杆状鞍座来固定杆，并允许外科医生野蛮地操纵杆。 在植入螺钉和插入杆之后，使用锁定螺钉来固定杆和螺钉体的角度和位置。

    Conditioned medium and proliferated cell lines produced therefrom
    9.
    发明授权
    Conditioned medium and proliferated cell lines produced therefrom 有权
    条件培养基和由其生产的增殖细胞系

    公开(公告)号：US08337829B2

    公开(公告)日：2012-12-25

    申请号：US13267346

    申请日：2011-10-06

    申请人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    发明人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    IPC分类号： C12N5/02 ,  C12N5/07 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/0789 ,  C12N5/0797 ,  C12N5/10

    CPC分类号： A61K35/26 ,  C12N5/0018 ,  C12N2500/84 ,  C12N2502/078 ,  C12N2502/30 ,  C12N2503/02

    摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

    摘要翻译： 本发明涉及可用于增加培养物中任何人或动物细胞的增殖潜力的肿瘤细胞系，从而提供永生化或连续的细胞系和培养物。 本发明还涉及增殖因子和含有因子的组合物，其能够增加培养物中任何人或其他动物细胞的增殖潜力。 本发明还涉及通过使细胞与增殖因子接触来增殖培养细胞的方法。 增殖的细胞可以在可塑性范围内，并且可以包括例如胚细胞，受精卵，非受精配子，胚胎干细胞，成体干细胞，前体或祖细胞和高度专门的细胞。 任选地，可诱导细胞停止增殖。 本发明的增殖细胞可用于细胞治疗，细胞/基因治疗，分子的生物制备，以及用于研究，毒性测试和药物开发的体外模型。

    Cervical plate system
    10.
    发明授权
    Cervical plate system 有权
    宫颈板系统

    公开(公告)号：US07963980B1

    公开(公告)日：2011-06-21

    申请号：US11736627

    申请日：2007-04-18

    申请人： Thomas B. Freeman ,  Wesley Johnson

    发明人： Thomas B. Freeman ,  Wesley Johnson

    IPC分类号： A61B17/80

    CPC分类号： A61B17/7059 ,  A61B17/1728 ,  A61B17/1757 ,  A61B17/8014 ,  A61B17/808

    摘要： An anti-subsidence, anti-translocation, fusion compression cervical plate system with interface visualization, drill guide and temporary pin is provided. In one embodiment the invention provides a vertebral plate for minimizing the ability of an inter-body cage, filled with bone (or BMP-soaked sponges, etc.), to telescope into the vertebral body and to minimize failure due to cages that telescope into adjacent vertebral bodies on a delayed basis after surgery, as well as creation of reverse lordosis due to such telescoping. Another embodiment provides method to reduce the gap between the inter-body cage and the vertebral body end plate intra-operatively using compression from the plate caused by an offset between the screw bores on the plate and the drill holes, as established with an asymmetric drill guide.

    摘要翻译： 提供了具有界面可视化的抗沉降，抗移位，融合压缩宫颈板系统，钻引导和临时引脚。 在一个实施例中，本发明提供了一种脊椎板，用于使填充有骨（或BMP-浸泡的海绵等）的体间笼子的能力最小化，以望远镜到椎体中并且将由于笼罩的望远镜 手术后延迟的相邻椎体，以及由于这种伸缩引起的反向脊柱前凸的产生。 另一个实施例提供了如下方法：使用由不对称钻头建立的板上螺钉孔与钻孔之间的偏移引起的板内压缩从而减小了体内笼与椎体内端板之间的间隙 指南。