公开(公告)号：US09895233B2

公开(公告)日：2018-02-20

申请号：US15425236

申请日：2017-02-06

申请人： GLOBUS MEDICAL, INC.

发明人： Damien O'Halloran ,  Jody L. Seifert ,  Jeff Bennett ,  Aditya Ingalhalikar ,  Sean Suh ,  Sophia Tetteh

IPC分类号： A61F2/44 ,  A61F2/46 ,  A61F2/30

CPC分类号： A61F2/442 ,  A61F2/30767 ,  A61F2/441 ,  A61F2/4611 ,  A61F2002/30064 ,  A61F2002/30069 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30291 ,  A61F2002/30565 ,  A61F2002/30586 ,  A61F2002/30588 ,  A61F2002/30616 ,  A61F2002/30677 ,  A61F2002/3082 ,  A61F2002/30841 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/4622 ,  A61F2002/4635 ,  A61F2230/0065 ,  A61F2230/0091 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00059 ,  A61F2310/00071

摘要： The invention encompasses devices and methods for treating one or more damaged, diseased, or traumatized intervertebral discs to reduce or eliminate associated back pain. Specifically, the invention encompasses intervertebral nucleus and annulus implants that are resistant to migration in and/or expulsion from an intervertebral disc space. The invention further encompasses kits including the implantable devices of the invention and associated delivery tools to treat annular and nuclear tissue.

公开(公告)号：US20170246005A1

公开(公告)日：2017-08-31

申请号：US15457194

申请日：2017-03-13

申请人： SPINAL STABILIZATION TECHNOLOGIES, LLC

发明人： Nadi Salah HIBRI ,  James Douglas LUTZ

IPC分类号： A61F2/44 ,  A61F2/46

CPC分类号： A61F2/441 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30006 ,  A61F2002/30009 ,  A61F2002/30069 ,  A61F2002/30074 ,  A61F2002/30563 ,  A61F2002/30583 ,  A61F2002/30584 ,  A61F2002/30586 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2210/0057 ,  A61F2210/0085 ,  A61F2250/0015 ,  A61F2250/0028

摘要： An inter-vertebral disc prosthesis intended for percutaneous deployment comprises an expandable annular enclosure and an expandable nuclear enclosure. The expandable annular enclosure incorporates a reinforcing annular band along its periphery and is filled with in-situ curable rubber. The expandable nuclear enclosure is filled with a gas. The nuclear prosthesis further incorporates a novel, integrally molded sealing valve assembly and is stretchable and collapsible into a minimal profile for ease of insertion into a specially designed delivery cannula, and is inflation-assisted expandable into an inter-vertebral disc in which complete percutaneous nuclectomy has been performed.

公开(公告)号：US20170071745A1

公开(公告)日：2017-03-16

申请号：US15360789

申请日：2016-11-23

申请人： Augusto Magagnoli

发明人： Augusto Magagnoli

IPC分类号： A61F2/30 ,  A61F2/38 ,  A61F2/40 ,  B22F5/00 ,  A61F2/28 ,  B29C45/00 ,  B28B1/24 ,  B22F3/105 ,  A61F2/36 ,  A61F2/46

CPC分类号： A61F2/3094 ,  A61F2/28 ,  A61F2/30965 ,  A61F2/36 ,  A61F2/3859 ,  A61F2/40 ,  A61F2/4684 ,  A61F2002/2835 ,  A61F2002/30004 ,  A61F2002/30586 ,  A61F2002/30672 ,  A61F2002/30677 ,  A61F2002/3092 ,  A61F2002/30932 ,  A61F2002/30957 ,  A61F2310/00353 ,  A61F2310/00952 ,  B22F3/1055 ,  B22F5/00 ,  B28B1/24 ,  B29C45/0013 ,  B29K2105/16 ,  B29K2995/0056 ,  B29L2031/7532

摘要： A method of making a spacer device or a device to be implanted in a human body that includes a containment body and is suitable for treating a bone seat or a joint seat of the human body includes a base portion and side walls that extend from the base portion and that delimit between them at least one cavity, wherein the containment body has a plurality of pores and/or at least one opening, configured to place the at least one internal cavity in communication with the outside of the containment body.

摘要翻译： 一种制造间隔装置或植入人体内的装置的方法，其包括容纳体并且适合于治疗人体的骨座或关节座，包括基部和从基部延伸的侧壁 并且在它们之间限定至少一个空腔，其中所述容纳体具有多个孔和/或至少一个开口，其被配置为将所述至少一个内部空腔与所述容纳体的外部连通。

公开(公告)号：US09592130B2

公开(公告)日：2017-03-14

申请号：US14098352

申请日：2013-12-05

申请人： Spinal Stabilization Technologies, LLC

发明人： Nadi Salah Hibri ,  James Douglas Lutz

IPC分类号： A61F2/44 ,  A61B17/15 ,  A61B17/17 ,  A61F2/46 ,  A61F2/30

CPC分类号： A61F2/441 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30006 ,  A61F2002/30009 ,  A61F2002/30069 ,  A61F2002/30074 ,  A61F2002/30563 ,  A61F2002/30583 ,  A61F2002/30584 ,  A61F2002/30586 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2210/0057 ,  A61F2210/0085 ,  A61F2250/0015 ,  A61F2250/0028

摘要： An inter-vertebral disc prosthesis intended for percutaneous deployment comprises an expandable annular enclosure and an expandable nuclear enclosure. The expandable annular enclosure incorporates a reinforcing annular band along its periphery and is filled with in-situ curable rubber. The expandable nuclear enclosure is filled with a gas. The nuclear prosthesis further incorporates a novel, integrally molded sealing valve assembly and is stretchable and collapsible into a minimal profile for ease of insertion into a specially designed delivery cannula, and is inflation-assisted expandable into an inter-vertebral disc in which complete percutaneous nuclectomy has been performed.

摘要翻译： 用于经皮部署的椎间盘假体包括可扩张的环形外壳和可扩张的核外壳。 可膨胀的环形外壳沿其周边结合有加强环形带，并填充有原位可固化的橡胶。 可膨胀核壳体充满气体。 核假体还包括一个新颖的，整体模制的密封阀组件，并且是可拉伸的并且可折叠成最小轮廓，以便于插入到特别设计的输送插管中，并且被充气辅助扩张成椎间盘，其中完全经皮切除术 已经执行。

公开(公告)号：US09533024B2

公开(公告)日：2017-01-03

申请号：US12775771

申请日：2010-05-07

申请人： Lionel C. Sevrain ,  Sylvie Y. Verdier-Sevrain

发明人： Lionel C. Sevrain ,  Sylvie Y. Verdier-Sevrain

IPC分类号： A61K38/18 ,  C12N5/00 ,  A61F2/30 ,  A61F2/44 ,  A61L27/38 ,  C12N5/077 ,  A61K45/06 ,  A61K35/32 ,  A61K35/33 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/28 ,  A61F2/46

CPC分类号： A61L27/3817 ,  A61F2/30756 ,  A61F2/3099 ,  A61F2/32 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/40 ,  A61F2/441 ,  A61F2002/2817 ,  A61F2002/286 ,  A61F2002/30062 ,  A61F2002/30586 ,  A61F2002/30677 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2002/4635 ,  A61F2210/0004 ,  A61K35/32 ,  A61K35/33 ,  A61K38/18 ,  A61K45/06 ,  A61L27/3852 ,  A61L27/3895 ,  A61L2430/06 ,  C12N5/0655 ,  C12N2500/02 ,  C12N2500/38 ,  C12N2501/155 ,  C12N2506/1307 ,  C12N2521/00 ,  C12N2533/74 ,  A61K2300/00

摘要： Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

公开(公告)号：US20160374821A1

公开(公告)日：2016-12-29

申请号：US15260465

申请日：2016-09-09

申请人： DePuy Synthes Products, Inc.

发明人： Thomas M. DiMauro ,  Michael Andrew Slivka

IPC分类号： A61F2/44

CPC分类号： A61F2/4455 ,  A61B17/00234 ,  A61F2/28 ,  A61F2/30965 ,  A61F2/441 ,  A61F2/442 ,  A61F2/4425 ,  A61F2/446 ,  A61F2/4465 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30065 ,  A61F2002/30092 ,  A61F2002/30131 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/3023 ,  A61F2002/30308 ,  A61F2002/30383 ,  A61F2002/30451 ,  A61F2002/3055 ,  A61F2002/30556 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30586 ,  A61F2002/30604 ,  A61F2002/30622 ,  A61F2002/30841 ,  A61F2002/30971 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2002/4677 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0061 ,  A61F2210/0071 ,  A61F2210/0085 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2230/0063 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2250/0003 ,  A61F2250/0009 ,  A61F2250/001 ,  A61F2250/003 ,  A61F2250/0065 ,  A61F2310/00011 ,  A61F2310/00179 ,  A61F2310/00365 ,  A61K9/0024 ,  A61K49/006 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/3821 ,  A61L27/3839 ,  A61L27/3847 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/38

摘要： An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon.In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

摘要翻译： 在一些实施例中，气囊具有基本上对应于椎骨终板的周边的足迹。 充气装置通过插管插入到椎间空间中并且定向成使得在膨胀时，椎骨之间的自然角度将被至少部分恢复。 选自承载组分和骨生物成分的组中的至少一种成分通过流体连通装置引导到可充气装置中。

公开(公告)号：US20160367380A1

公开(公告)日：2016-12-22

申请号：US15188179

申请日：2016-06-21

申请人： DePuy Synthes Products, Inc.

发明人： Thomas M. DiMauro

IPC分类号： A61F2/44

CPC分类号： A61F2/4455 ,  A61B17/00234 ,  A61F2/28 ,  A61F2/30965 ,  A61F2/441 ,  A61F2/442 ,  A61F2/4425 ,  A61F2/446 ,  A61F2/4465 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30065 ,  A61F2002/30092 ,  A61F2002/30131 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/3023 ,  A61F2002/30308 ,  A61F2002/30383 ,  A61F2002/30451 ,  A61F2002/3055 ,  A61F2002/30556 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30586 ,  A61F2002/30604 ,  A61F2002/30622 ,  A61F2002/30841 ,  A61F2002/30971 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2002/4677 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0061 ,  A61F2210/0071 ,  A61F2210/0085 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2230/0063 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2250/0003 ,  A61F2250/0009 ,  A61F2250/001 ,  A61F2250/003 ,  A61F2250/0065 ,  A61F2310/00011 ,  A61F2310/00179 ,  A61F2310/00365 ,  A61K9/0024 ,  A61K49/006 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/3821 ,  A61L27/3839 ,  A61L27/3847 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/38

摘要： An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon.In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

公开(公告)号：US09486323B1

公开(公告)日：2016-11-08

申请号：US14934987

申请日：2015-11-06

申请人： SPINAL STABILIZATION TECHNOLOGIES LLC

发明人： Nadi S. Hibri ,  W. Loren Francis ,  Mark A. Novotny

IPC分类号： A61F2/44

CPC分类号： A61F2/441 ,  A61F2/30749 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30069 ,  A61F2002/30505 ,  A61F2002/30576 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30586 ,  A61F2002/30971 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/4615

摘要： An expandable implant for augmenting a damaged or otherwise torn posterior annulus fibrosus. The implant is deployable into an evacuated posterior disc space following a subtotal nuclectomy. The implant includes an inflatable balloon which is fixed to the annulus fibrosus to protect against migration. When inflated with a curable polymer, the posterior wall of the implant is intimately disposed along the inner surface of the annulus fibrosus to provide a substantially fluid-tight seal of the annular tear or defect and reinforce the weakened posterior annulus. The anterior wall of the implant sequesters the nuclear remnant to guard against disc remnant herniation. The implant can restore intradiscal pressure and disc height. An integrated posterior reinforcement band creates a strong, yet flexible and resilient structure, resistant to penetration of the implant through the annular tear or defect.

摘要翻译： 用于增加损伤或其他撕裂的后纤维环的可扩张植入物。 小切口切除术后，植入物可部署到撤离后的椎间盘内。 植入物包括可膨胀气囊，其被固定到纤维环上以防止迁移。 当用可固化聚合物充气时，植入物的后壁沿着纤维环的内表面紧密地设置，以提供环形撕裂或缺损的基本上流体密封的密封，并加强弱化的后环。 植入物的前壁隔离核残留物以防止椎间盘残留突出。 植入物可以恢复椎间盘内压力和椎间盘高度。 一体化后部加固带产生强大而又柔性和弹性的结构，抵抗植入物通过环形撕裂或缺陷的穿透。

公开(公告)号：US09439776B2

公开(公告)日：2016-09-13

申请号：US14640741

申请日：2015-03-06

申请人： DePuy Synthes Products, Inc.

发明人： Thomas M. DiMauro ,  Michael Andrew Slivka

IPC分类号： A61F2/44 ,  A61F2/46 ,  A61L27/18 ,  A61L27/50 ,  A61L27/54 ,  A61B17/00 ,  A61F2/28 ,  A61F2/30

CPC分类号： A61F2/4455 ,  A61B17/00234 ,  A61F2/28 ,  A61F2/30965 ,  A61F2/441 ,  A61F2/442 ,  A61F2/4425 ,  A61F2/446 ,  A61F2/4465 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30065 ,  A61F2002/30092 ,  A61F2002/30131 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/3023 ,  A61F2002/30308 ,  A61F2002/30383 ,  A61F2002/30451 ,  A61F2002/3055 ,  A61F2002/30556 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30586 ,  A61F2002/30604 ,  A61F2002/30622 ,  A61F2002/30841 ,  A61F2002/30971 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2002/4677 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0061 ,  A61F2210/0071 ,  A61F2210/0085 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2230/0063 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2250/0003 ,  A61F2250/0009 ,  A61F2250/001 ,  A61F2250/003 ,  A61F2250/0065 ,  A61F2310/00011 ,  A61F2310/00179 ,  A61F2310/00365 ,  A61K9/0024 ,  A61K49/006 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/3821 ,  A61L27/3839 ,  A61L27/3847 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/38

摘要： An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon.In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

摘要翻译： 在一些实施例中，气囊具有基本上对应于椎骨终板的周边的足迹。 充气装置通过插管插入到椎间空间中并且定向成使得在膨胀时，椎骨之间的自然角度将被至少部分恢复。 选自承载组分和骨生物成分的组中的至少一种成分通过流体连通装置引导到可充气装置中。

公开(公告)号：US09358120B2

公开(公告)日：2016-06-07

申请号：US13804336

申请日：2013-03-14

申请人： DePuy Synthes Products, Inc.

发明人： Joern Richter ,  Jacques Teisen

IPC分类号： A61F2/44 ,  A61F2/46 ,  A61B17/70 ,  A61B17/88 ,  A61B17/02 ,  A61F2/28 ,  A61F2/30

CPC分类号： A61F2/442 ,  A61B17/7097 ,  A61B17/8811 ,  A61B17/8855 ,  A61B2017/0256 ,  A61F2/44 ,  A61F2/441 ,  A61F2/4455 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30019 ,  A61F2002/30056 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30092 ,  A61F2002/30153 ,  A61F2002/30235 ,  A61F2002/30263 ,  A61F2002/30289 ,  A61F2002/30291 ,  A61F2002/30331 ,  A61F2002/30462 ,  A61F2002/30484 ,  A61F2002/3052 ,  A61F2002/30556 ,  A61F2002/30563 ,  A61F2002/30581 ,  A61F2002/30583 ,  A61F2002/30584 ,  A61F2002/30586 ,  A61F2002/30588 ,  A61F2002/30594 ,  A61F2002/30601 ,  A61F2002/30677 ,  A61F2002/30772 ,  A61F2002/30784 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2002/4683 ,  A61F2002/4688 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00047 ,  A61F2310/00071

摘要： Coiled spinal implants for disc, vertebral body, and spinal motion segment replacement or reconstruction comprise a plurality of loops and spaces between the loops, with the loops formed of a hollow material and having a plurality of apertures or a longitudinal gap that extend(s) through the sidewalls of the loops and into the hollow center. The coiled implants include one or more balloons within the hollow center, the spaces between the coil loops, and/or within the central void that the coil surrounds. Filling the balloon expands the loops and thereby increases the height of the coil. Bone graft material or bone cement may be deployed from the apertures or gap.

摘要翻译： 用于盘，椎体和脊柱运动段更换或重建的盘状脊椎植入物包括环之间的多个环和间隔，其中环由中空材料形成，并且具有多个孔或纵向间隙， 通过环的侧壁并进入中空中心。 螺旋植入物包括中空中心内的一个或多个气囊，线圈环之间的空间和/或线圈围绕的中心空隙内。 填充气球会膨胀环，从而增加线圈的高度。 骨移植材料或骨粘固剂可以从孔或间隙展开。