公开(公告)号：US5254258A

公开(公告)日：1993-10-19

申请号：US761212

申请日：1991-09-17

申请人： William H. Pirkle ,  John A. Burke, III

发明人： William H. Pirkle ,  John A. Burke, III

IPC分类号： C07D205/085 ,  C07F7/18 ,  C07F9/40 ,  B01D61/38

CPC分类号： C07F7/1836 ,  C07D205/085 ,  C07F9/4015

摘要： Underivatized enantiomers of a beta -amino alcohol compound are directly separated by means of a chiral selector compound having the formula I wherein R2 and R3 are each independently lower alkyl, preferably methyl; R4 and R5 are each independently NO2, N(R6)3+, CN, COOR2, SO3H or COR8, preferably NO2; R6, R7 and R8 are each independently hydrogen or lower alkyl, preferably hydrogen or methyl, W is H or CH=CH2, X and Y are each independently OR9 or NR10R11, preferably X and Y are the same and most preferably X and Y are each OR9, or X and Y together with the P to which they are attached form a 5- or 6-membered ring having the formula R9, R10, R11 and R12 are each independently hydrogen or lower alkyl, R9 is preferably methyl, R10, R11 and R12 are preferably hydrogen or methyl, Z is O or NH, n is 1 to 20, preferably 1 to 8 when W is H, and 1 to 3 when W is CH=CH2, and m is 1 or 2, said compound being an R or an S enantiomer or a mixture of R and S enantiomers.

摘要翻译： β-氨基醇化合物的未衍生的对映异构体通过具有下式的手性选择化合物直接分离：其中R 2和R 3各自独立地为低级烷基，优选甲基; R 4和R 5各自独立地为NO 2，N（R 6）3+，CN，COOR 2，SO 3 H或COR 8，优选为NO 2; R 6，R 7和R 8各自独立地为氢或低级烷基，优选氢或甲基，W为H或CH = CH 2，X和Y各自独立地为OR 9或NR 10 R 11，优选X和Y为相同且最优选X和Y为 每个OR 9或X和Y与它们所连接的P一起形成具有下式的5-或6-元环：R 9，R 10，R 11和R 12各自独立地为氢或低级烷基，R 9优选为甲基 R 10，R 11和R 12优选为氢或甲基，Z为O或NH，当W为H时，n为1至20，优选1至8，W为CH = CH 2时为1至3，m为1或2 所述化合物是R或S对映体或R和S对映异构体的混合物。