公开(公告)号：US20140336105A1

公开(公告)日：2014-11-13

申请号：US14323408

申请日：2014-07-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Yechiel Shai ,  Avner Fink ,  Shay Yaari ,  Tova Waks ,  Zelig Eshhar ,  Christopher J. Arnush

IPC: C07K7/08 ,  C07K14/00

CPC classification number: C07K7/08 ,  A61K38/08 ,  C07K7/00 ,  C07K14/001

Abstract: Anti-inflammatory peptides and pharmaceutical compositions including lysine, alanine, leucine and/or valine for treating inflammatory conditions and uses thereof. Anti-inflammatory peptides for treating IgE-mediated allergies and inflammatory conditions caused by a microbial infection including but not limited to sepsis.

Abstract translation: 抗炎肽和药物组合物，包括用于治疗炎性病症的赖氨酸，丙氨酸，亮氨酸和/或缬氨酸及其用途。 用于治疗由微生物感染引起的IgE介导的过敏和炎性病症的抗炎肽，包括但不限于败血症。

公开(公告)号：US09346854B2

公开(公告)日：2016-05-24

申请号：US14323408

申请日：2014-07-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yechiel Shai ,  Avner Fink ,  Shay Yaari ,  Tova Waks ,  Zelig Eshhar ,  Christopher J. Arnush

IPC: C07K7/00 ,  C07K7/08 ,  A61K38/08 ,  C07K14/00

CPC classification number: C07K7/08 ,  A61K38/08 ,  C07K7/00 ,  C07K14/001

Abstract: Isolated peptides of 13-30 amino acids comprising 5-9 consecutive repeats of the amino acid pair Alanine-Leucine or Alanine-Valine are provided. The peptides further comprise a stretch of 1-3 Lysine residues present at least at one of the peptide's termini, wherein the only Lysine residue in the isolated peptide is present at the stretch of 1-3 Lysine residues. Pharmaceutical compositions comprising same, methods of treating inflammatory conditions and allergic reactions, as well as methods of neutralizing the activity of lypopolysaccharides are also provided.

Abstract translation: 提供了包含氨基酸对丙氨酸 - 亮氨酸或丙氨酸 - 缬氨酸的5-9个连续重复的13-30个氨基酸的分离的肽。 所述肽还包含存在于至少一个肽末端的1-3个赖氨酸残基，其中分离的肽中唯一的赖氨酸残基以1-3个赖氨酸残基的一段存在。 还提供了包含其的药物组合物，治疗炎性病症和过敏反应的方法，以及中和赖福多糖活性的方法。