公开(公告)号：US20200256857A1

公开(公告)日：2020-08-13

申请号：US16783524

申请日：2020-02-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MARGULIES ,  Leila MOTIEI ,  Naama LAHAV

IPC: G01N33/533 ,  C07D249/04 ,  G01N33/58 ,  G01N33/68

Abstract: This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.

公开(公告)号：US20220236257A1

公开(公告)日：2022-07-28

申请号：US17614563

申请日：2019-06-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MARGULIES ,  Leila MOTIEI ,  Naama LAHAV

IPC: G01N33/532 ,  C07K14/705 ,  G01N33/50 ,  C12N5/00 ,  C12N1/00 ,  C12Q1/02

Abstract: The disclosure presented herein provides artificial receptors and a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.