公开(公告)号：US20200325120A1

公开(公告)日：2020-10-15

申请号：US16096712

申请日：2017-04-26

申请人： YUHAN CORPORATION

发明人： Young-Hwan KIM ,  Tae-Dong HAN ,  Dong-Hoon KIM ,  Eun-Hye JUNG ,  Su-Bin CHOI ,  Eui-Chul LEE ,  Won-Ee CHONG ,  Jin-Hwi PARK ,  Jun-Chul PARK ,  Ho-Woong KANG ,  Ji-Yeong GAL ,  Chan-Sun PARK ,  Jong-Gyun KIM ,  Su-Youn NAM

IPC分类号： C07D403/14 ,  C07D239/91 ,  C07D217/24 ,  C07D403/12

摘要： The present invention provides a quinazoline derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The quinazoline derivative or its pharmaceutically acceptable salt has a selective inhibitory activity against the phosphatidylinositol 3-kinase delta subunit, and therefore can be usefully applied for preventing or treating cancer, along with avoiding side effects such as lymphopenia-associated inflammatory responses.