公开(公告)号：US20200325120A1

公开(公告)日：2020-10-15

申请号：US16096712

申请日：2017-04-26

申请人： YUHAN CORPORATION

发明人： Young-Hwan KIM ,  Tae-Dong HAN ,  Dong-Hoon KIM ,  Eun-Hye JUNG ,  Su-Bin CHOI ,  Eui-Chul LEE ,  Won-Ee CHONG ,  Jin-Hwi PARK ,  Jun-Chul PARK ,  Ho-Woong KANG ,  Ji-Yeong GAL ,  Chan-Sun PARK ,  Jong-Gyun KIM ,  Su-Youn NAM

IPC分类号： C07D403/14 ,  C07D239/91 ,  C07D217/24 ,  C07D403/12

摘要： The present invention provides a quinazoline derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The quinazoline derivative or its pharmaceutically acceptable salt has a selective inhibitory activity against the phosphatidylinositol 3-kinase delta subunit, and therefore can be usefully applied for preventing or treating cancer, along with avoiding side effects such as lymphopenia-associated inflammatory responses.

公开(公告)号：US20230002379A1

公开(公告)日：2023-01-05

申请号：US17755843

申请日：2020-11-12

申请人： YUHAN CORPORATION ,  GREEN CROSS CORPORATION

发明人： Dong-Hoon KIM ,  Jae-Eun JOO ,  Eui-Chul LEE ,  Tae-Dong HAN ,  Seung-Yub SHIN ,  Sool-Ki KWON ,  Ji-Hye KIM

IPC分类号： C07D471/08

摘要： Provided are a compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and a use thereof, where the compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

公开(公告)号：US20160068515A1

公开(公告)日：2016-03-10

申请号：US14786837

申请日：2014-04-22

申请人： YUHAN CORPORATION

发明人： Tae-Dong HAN ,  Eun-Hye JUNG ,  Chung-Ho YI ,  Byoung-Moon LEE ,  Yoo-Hoi PARK ,  Dong-Hoon LEE ,  Jong-Ho KANG ,  Na-Yeon YANG ,  Do-Hoon KIM ,  Kwan-Hoon HYUN ,  Kaap-Joo PARK ,  Chun-Ho LEE ,  Su-Youn NAM

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D403/04 ,  C07D405/06 ,  C07D405/14 ,  C07D249/12 ,  C07D405/04

CPC分类号： C07D401/14 ,  C07D249/12 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D413/14

摘要： Provided is a triazolone derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The triazolone derivative or its pharmaceutically acceptable salt can effectively activate GPR119; and therefore be usefully applied for preventing or treating diabetes mellitus.

摘要翻译： 本发明提供三唑酮衍生物或其药学上可接受的盐，其制备方法和包含其的药物组合物。 三唑酮衍生物或其药学上可接受的盐可以有效激活GPR119; 因此可用于预防或治疗糖尿病。

公开(公告)号：US20230002380A1

公开(公告)日：2023-01-05

申请号：US17755858

申请日：2020-11-12

申请人： YUHAN CORPORATION ,  GREEN CROSS CORPORATION

发明人： Dong-Hoon KIM ,  Jae-Eun JOO ,  Eui-Chul LEE ,  Tae-Dong HAN ,  Seung-Yub SHIN ,  Sool-Ki KWON

IPC分类号： C07D471/08

摘要： Provided are a compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

公开(公告)号：US20220402909A1

公开(公告)日：2022-12-22

申请号：US17755852

申请日：2020-11-12

申请人： YUHAN CORPORATION ,  GREEN CROSS CORPORATION

发明人： Dong-Hoon KIM ,  Jae-Eun JOO ,  Eui-Chul LEE ,  Tae-Dong HAN ,  Seung-Yub SHIN ,  Sool-Ki KWON ,  Young-Gyu KONG ,  Sang-Ho MA ,  Ick-Hwan SON

IPC分类号： C07D453/02 ,  C07D519/00 ,  A61P3/00

摘要： Provided are a compound having a 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and a use thereof, where the compound having a 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.