公开(公告)号：US20160354410A1

公开(公告)日：2016-12-08

申请号：US15242666

申请日：2016-08-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Assaf LASK ,  Eran OPHIR ,  Noga OR-GEVA ,  Adva COHEN ,  Ran AFIK ,  Esther BACHAR-LUSTIG ,  Yaki EIDELSTEIN

IPC: A61K35/17 ,  A61K35/28 ,  C12N5/0783 ,  A61K45/06

CPC classification number: A61K35/17 ,  A61K31/517 ,  A61K35/28 ,  A61K39/001 ,  A61K45/06 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0602 ,  C12N5/0636 ,  C12N5/0637 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  A61K2300/00

Abstract: A method of treating a disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting a non-syngeneic cell or tissue graft to the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of cells comprising non-graft versus host (GVHD) inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, and further wherein the cells are either: (i) non-syngeneic with both the subject and the graft; or (ii) non-syngeneic with the graft and syngeneic with the subject, thereby treating the subject.