公开(公告)号：US20040235729A1

公开(公告)日：2004-11-25

申请号：US10620621

申请日：2003-07-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Edna Mozes ,  Ari Waisman

IPC: A61K038/10 ,  A61K038/08

CPC classification number: G01N33/564 ,  A61K38/00 ,  A61K47/62 ,  C07K16/18 ,  C07K2317/73 ,  G01N2800/104

Abstract: Synthetic peptides based on a complementarity-determining region (CDR) of the heavy or light chain of a pathogenic anti-DNA monoclonal antibody that induces a systemic lupus erythematosus (SLE)-like disease in mice, and analogs, and salts and chemical derivatives thereof; dual peptides comprising two such peptides or analogs covalently linked to one another either directly or through a short linking chain; peptide polymers comprising a plurality of sequences of said peptide or analog thereof; and peptide polymers attached to a macromolecular carrier, are disclosed, and pharmaceutical compositions comprising them for the treatment of SLE in humans.

Abstract translation: 基于诱导小鼠系统性红斑狼疮（SLE）样疾病的病原性抗DNA单克隆抗体的重链或轻链的互补决定区（CDR）的合成肽及其类似物及其盐及其化学衍生物 ; 包含两个这样的肽的双肽或直接或通过短连接链彼此共价连接的类似物; 包含所述肽或其类似物的多个序列的肽聚合物; 和与大分子载体连接的肽聚合物，以及包含它们的药物组合物用于治疗人类中的SLE。