公开(公告)号：US20240325574A1

公开(公告)日：2024-10-03

申请号：US18625695

申请日：2024-04-03

申请人： MOLECULAR THERANOSTICS, LLC

发明人： Songqui Gao ,  Michael Tweedle ,  Yajuan Li ,  Zheng-Rong Lu

IPC分类号： A61K49/10 ,  A61K47/62 ,  A61K49/00

CPC分类号： A61K49/106 ,  A61K47/62 ,  A61K49/0032 ,  A61K2123/00

摘要： Molecular probe compounds according to the formula P-L-I are described. P is a targeting peptide selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 117; I is an imaging agent; and L is an optional non-peptide linker that covalently links the peptide to the imaging agent, wherein the linker comprises a carboxylic acid that forms a carboxamide with an amine of the targeting peptide or a maleimide that forms a thioester bond with a cysteine residue of the targeting peptide. Methods of detecting cancer and monitoring the treatment of cancer using the molecular probes are also described.

公开(公告)号：US20240270803A1

公开(公告)日：2024-08-15

申请号：US18408527

申请日：2024-01-09

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Tatsuya Inoue

IPC分类号： C07K14/47 ,  A61K38/00 ,  A61K45/06 ,  A61K47/62 ,  A61P27/02 ,  C12Q1/37

CPC分类号： C07K14/4703 ,  A61K45/06 ,  A61K47/62 ,  A61P27/02 ,  C12Q1/37 ,  A61K38/00

摘要： To provide a novel pharmaceutical use of a peptide. A pharmaceutical composition for the treatment or prevention of retinitis pigmentosa, comprising a peptide which comprises the amino acid sequence shown in SEQ ID NO: 30 and inhibits a protease activity.

公开(公告)号：US20240261429A1

公开(公告)日：2024-08-08

申请号：US18569998

申请日：2022-06-15

申请人： The Regents of the University of California

发明人： Nicole Steinmetz ,  Soo Khim Chan

IPC分类号： A61K47/69 ,  A61K47/62 ,  C07K7/06 ,  C07K14/005

CPC分类号： A61K47/6901 ,  A61K47/62 ,  C07K7/06 ,  C07K14/005 ,  C07K2319/00 ,  C12N2770/18022 ,  C12N2770/18023

摘要： This disclosure provides a conjugate comprising a 7-mer peptide bound to the surface of a viral particle such as cowpea mosaic virus (CPMV). The c terminus of this peptide can be conjugated to desired molecules with the N terminus of the peptide interacting with CPMV surface.

公开(公告)号：US12023391B2

公开(公告)日：2024-07-02

申请号：US17504072

申请日：2021-10-18

申请人： The Regents of the University of California

发明人： Yng Tang ,  Julie L. Sutcliffe

IPC分类号： A61K51/08 ,  A61B5/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K47/60 ,  A61K47/62 ,  C07K7/06 ,  C07K7/08

CPC分类号： A61K51/088 ,  A61B5/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1777 ,  A61K47/60 ,  A61K47/62 ,  C07K7/06 ,  C07K7/08

摘要： The present invention provides peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates comprise a moiety such as a PEG moiety, an imaging agent, or a therapeutic agent. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue. Compositions and kits containing the peptide conjugates of the present invention are also provided herein.

公开(公告)号：US20240189436A1

公开(公告)日：2024-06-13

申请号：US18499739

申请日：2023-11-01

申请人： BicycleTx Limited

发明人： Liuhong CHEN ,  Philip HUXLEY ,  Silvia PAVAN ,  Katerine VAN RIETSCHOTEN

IPC分类号： A61K47/64 ,  A61K38/05 ,  A61K38/10 ,  A61K47/62 ,  A61K47/65 ,  A61P35/00 ,  C07K7/08

CPC分类号： A61K47/6415 ,  A61K38/05 ,  A61K38/10 ,  A61K47/62 ,  A61K47/64 ,  A61K47/65 ,  A61P35/00 ,  C07K7/08

摘要： The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of the Eph receptor tyrosine kinase A2 (EphA2). The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder characterised by overexpression of EphA2 in diseased tissue (such as a tumour).

公开(公告)号：US20240156970A1

公开(公告)日：2024-05-16

申请号：US18550659

申请日：2022-03-14

申请人： GRIFFITH UNIVERSITY ,  University of Iowa Research Foundation

发明人： Michael Jennings ,  Feda (En-Chi) Jen ,  Kate Seib ,  Evegny Semchenko ,  Milton Kiefel ,  Michael Apicella

IPC分类号： A61K47/62 ,  A61K39/00 ,  A61K39/095

CPC分类号： A61K47/62 ,  A61K39/095 ,  A61K2039/6037 ,  A61K2039/6081

摘要： This disclosure relates generally to Neisseria surface moieties. More particularly, the present disclosure relates to oligosaccharides corresponding to Neisseria lipooligosaccharides and to chimeric molecules comprising these moieties for eliciting an immune response to Neisseria organisms and/or for treating or inhibiting the development of Neisseria infections.

公开(公告)号：US11981719B2

公开(公告)日：2024-05-14

申请号：US16954902

申请日：2018-12-20

申请人： Alteogen, Inc.

发明人： Soon Jae Park ,  Jaehyeong Ko ,  Sun-Ah You ,  Sang Hoon Yun

IPC分类号： A61K38/00 ,  A61K47/62 ,  C07K14/61 ,  C07K14/81

CPC分类号： C07K14/61 ,  A61K47/62 ,  C07K14/8125 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to a growth hormone receptor antagonist comprising a growth hormone variant which is modified by substitution of one or more amino acids of growth hormone. Further, the growth hormone receptor antagonist of the present invention may further comprise a long-acting carrier which is fused to the growth hormone variant. The growth hormone receptor antagonist may have strong binding potency to growth hormone receptor and may exhibit a long-lasting antagonistic action.

公开(公告)号：US11951178B2

公开(公告)日：2024-04-09

申请号：US17375548

申请日：2021-07-14

申请人： University of Cincinnati ,  The Board of Trustees of the University of Illinois ,  The University of Chicago

发明人： Jianjun Chen ,  Seungpyo Hong ,  Xi Jiang ,  Zejuan Li

IPC分类号： C12N15/11 ,  A61K31/551 ,  A61K31/7105 ,  A61K38/19 ,  A61K45/06 ,  A61K47/59 ,  A61K47/62 ,  A61K47/69 ,  A61P35/02 ,  C12N15/113

CPC分类号： A61K47/6935 ,  A61K31/551 ,  A61K31/7105 ,  A61K38/19 ,  A61K45/06 ,  A61K47/595 ,  A61K47/62 ,  A61P35/02 ,  C12N15/1138 ,  C12N2310/141 ,  C12N2310/321 ,  A61K31/551 ,  A61K2300/00

摘要： A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3-overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided.

公开(公告)号：US11878063B2

公开(公告)日：2024-01-23

申请号：US16810783

申请日：2020-03-05

申请人： Children's Medical Center Corporation ,  The General Hospital Corporation

发明人： Ross Cheloha ,  Hidde L. Ploegh ,  Thomas J. Gardella

IPC分类号： A61K47/68 ,  A61K47/62

CPC分类号： A61K47/6849 ,  A61K47/62

摘要： Described herein are engineered ligand that binds a cell surface receptor (e.g., GPCR), with improved affinity, potency, and specificity. By conjugating a sub-optimal ligand for a cell surface receptor (e.g., GPCR) to a targeting molecule that binds an epitope (natural or exogenous epitope) in the extracellular portion of the cell surface receptor (e.g., GPCR), the affinity, potency, and/or specificity of the sub-optimal ligand is enhanced.

公开(公告)号：US11851469B2

公开(公告)日：2023-12-26

申请号：US15524370

申请日：2015-11-04

申请人： XLIFESC, LTD.

发明人： Yi Li ,  Hui Fan

IPC分类号： C07K14/725 ,  A61K38/17 ,  C12N15/63 ,  A61K47/62 ,  C07K16/28 ,  A61K38/00

CPC分类号： C07K14/7051 ,  A61K38/17 ,  A61K47/62 ,  C07K16/2809 ,  C12N15/63 ,  A61K38/00 ,  C07K2319/30

摘要： Provided is a high-stability T cell receptor (TCR). The TCR comprises (i) the whole or a part of TCRα chain except a transmembrane domain thereof, and (ii) the whole or a part of TCRβ chain except a transmembrane domain thereof, both the (i) and the (ii) comprising a functional variable domain and at least a part of a constant domain of a TCR chain. An artificial interchain disulfide bond links the constant domains of the TCRα and β chains, and a Tm value of the T cell receptor is greater than or equal to 45° C.