公开(公告)号：US20240180966A1

公开(公告)日：2024-06-06

申请号：US18384390

申请日：2023-10-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Nir FRIEDMAN ,  Aviyah PERI ,  Erez GREENSTEIN ,  Michal ALON

IPC: A61K35/17 ,  A61K39/00

CPC classification number: A61K35/17 ,  A61K39/4611 ,  A61K2239/57

Abstract: A method of treating cancer in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a population of T cells, wherein an alpha chain of a TCR of at least 10% of the T cells of the population has a CDR3 amino acid sequence as set forth in SEQ ID NO: 6, and a beta chain of the CDR has a CDR3 amino acid sequence as set forth in SEQ ID NO: 7.

公开(公告)号：US20220241331A1

公开(公告)日：2022-08-04

申请号：US17612279

申请日：2020-05-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Shelly KALAORA ,  Aviyah PERI ,  Nir FRIEDMAN ,  Shlomit REICH-ZELIGER ,  Erez GREENSTEIN

IPC: A61K35/17 ,  C07K14/47 ,  C07K14/725 ,  C07K14/82 ,  C12N5/0783

Abstract: A method of treating cancer in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of T cells expressing a T cell receptor (TCR) having a CDR3 amino acid sequence selected from the group consisting of 199-210.