公开(公告)号：US20220241331A1

公开(公告)日：2022-08-04

申请号：US17612279

申请日：2020-05-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Shelly KALAORA ,  Aviyah PERI ,  Nir FRIEDMAN ,  Shlomit REICH-ZELIGER ,  Erez GREENSTEIN

IPC: A61K35/17 ,  C07K14/47 ,  C07K14/725 ,  C07K14/82 ,  C12N5/0783

Abstract: A method of treating cancer in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of T cells expressing a T cell receptor (TCR) having a CDR3 amino acid sequence selected from the group consisting of 199-210.

公开(公告)号：US20240180966A1

公开(公告)日：2024-06-06

申请号：US18384390

申请日：2023-10-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Nir FRIEDMAN ,  Aviyah PERI ,  Erez GREENSTEIN ,  Michal ALON

IPC: A61K35/17 ,  A61K39/00

CPC classification number: A61K35/17 ,  A61K39/4611 ,  A61K2239/57

Abstract: A method of treating cancer in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a population of T cells, wherein an alpha chain of a TCR of at least 10% of the T cells of the population has a CDR3 amino acid sequence as set forth in SEQ ID NO: 6, and a beta chain of the CDR has a CDR3 amino acid sequence as set forth in SEQ ID NO: 7.

公开(公告)号：US20210315983A1

公开(公告)日：2021-10-14

申请号：US17092386

申请日：2019-05-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Yochai WOLF ,  Osnat BARTOK

IPC: A61K39/00 ,  A61P35/00 ,  C12N5/09 ,  G01N33/574

Abstract: A method of identifying a neoantigen in a tumor of a subject is disclosed. The method comprises:
(a) culturing cells of the tumor under conditions which generate single cell clones of the tumor; and
(b) analyzing the single cell clones for expression of a neoantigen which is reactive with T cells from the subject, thereby identifying the neoantigen in a tumor of a subject.

公开(公告)号：US20210154261A1

公开(公告)日：2021-05-27

申请号：US16633175

申请日：2018-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Rand ARAFEH ,  Karen FLORES ,  Rony SEGER ,  Ehud WAINSTEIN

IPC: A61K38/10 ,  A61K31/519 ,  A61K31/4184 ,  A61P35/00

Abstract: An article of manufacture is disclosed which comprises: (i) a peptide agent which is capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus; and (ii) a MEK inhibitor. Uses thereof are also disclosed.