公开(公告)号：US10066014B2

公开(公告)日：2018-09-04

申请号：US15116276

申请日：2015-02-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Idit Shachar ,  Inbal Binsky ,  Ayelet Marom

IPC: C07K16/28 ,  G01N33/574 ,  C07K16/30 ,  G01N33/50 ,  A61K39/395

Abstract: An isolated antibody comprising an antigen recognition domain which specifically binds CD84 and (i) down regulates the anti-apoptotic activity of stromal cells on chronic lymphocytic leukemia (CLL) cells; and/or (ii) induces mobilization of CLL cells from the bone marrow. Also provided are antibodies comprising antigen recognition domains comprising complementarity determining regions as indicated and uses thereof.