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公开(公告)号：US10329347B2
公开(公告)日：2019-06-25
申请号：US14827337
申请日：2015-08-17
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Idit Shachar , Inbal Binsky , Mirko Sobotta
IPC: G01N33/574 , C07K16/28 , C07K14/705 , C12Q1/6886 , A61K38/00
Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
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公开(公告)号：US10066014B2
公开(公告)日：2018-09-04
申请号：US15116276
申请日：2015-02-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Idit Shachar , Inbal Binsky , Ayelet Marom
IPC: C07K16/28 , G01N33/574 , C07K16/30 , G01N33/50 , A61K39/395
Abstract: An isolated antibody comprising an antigen recognition domain which specifically binds CD84 and (i) down regulates the anti-apoptotic activity of stromal cells on chronic lymphocytic leukemia (CLL) cells; and/or (ii) induces mobilization of CLL cells from the bone marrow. Also provided are antibodies comprising antigen recognition domains comprising complementarity determining regions as indicated and uses thereof.
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3.发明授权Compositions comprising soluble CD84 or anti-CD84 antibodies and methods for diagnosing and treating B-CLL 有权包含可溶性CD84或抗CD84抗体的组合物和用于诊断和治疗B-CLL的方法公开(公告)号：US09109029B2
公开(公告)日：2015-08-18
申请号：US14172926
申请日：2014-02-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Idit Shachar , Inbal Binsky , Mirko Sobotta
IPC: A61K39/395 , C07K16/00 , C07K16/28 , C07K14/705 , G01N33/574 , C12Q1/68 , A61K38/00
CPC classification number: C07K16/2803 , A61K38/00 , C07K14/70596 , C12Q1/6886 , C12Q2600/156 , G01N33/57426 , G01N2333/70507
Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
Abstract translation: 提供了在有需要的受试者中诊断B-CLL的方法。 该方法包括在受试者的生物样品中测定CD84同种型C（SEQ ID NO：30）的水平，其中相对于CD84同种型C（SEQ ID NO：30）的CD84同种型C（SEQ ID NO：30）的水平增加超过预定阈值 来自健康个体的生物样品中的CD84水平表示B-CLL。
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4.发明申请COMPOSITIONS COMPRISING SOLUBLE CD84 OR ANTI-CD84 ANTIBODIES AND METHODS FOR DIAGNOSING AND TREATING B-CLL 有权包含可溶性CD84或抗CD84抗体的组合物和用于诊断和治疗B-CLL的方法公开(公告)号：US20140147451A1
公开(公告)日：2014-05-29
申请号：US14172926
申请日：2014-02-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Idit SHACHAR , Inbal Binsky , Mirko Sobotta
IPC: C07K16/28 , C12Q1/68 , G01N33/574
CPC classification number: C07K16/2803 , A61K38/00 , C07K14/70596 , C12Q1/6886 , C12Q2600/156 , G01N33/57426 , G01N2333/70507
Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
Abstract translation: 提供了在有需要的受试者中诊断B-CLL的方法。 该方法包括在受试者的生物样品中测定CD84同种型C（SEQ ID NO：30）的水平，其中相对于CD84同种型C（SEQ ID NO：30）的CD84同种型C（SEQ ID NO：30）的水平增加超过预定阈值 来自健康个体的生物样品中的CD84水平表示B-CLL。
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