公开(公告)号：US20150307883A1

公开(公告)日：2015-10-29

申请号：US14439248

申请日：2013-10-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef YARDEN ,  Michael SELA ,  Georg MAHLKNECHT ,  Ruth MARON ,  Bilha SCHECHTER

IPC: C12N15/115 ,  G01N33/574

CPC classification number: C12N15/115 ,  A61K31/7088 ,  C12N2310/16 ,  C12N2310/351 ,  C12N2310/3517 ,  C12N2310/51 ,  C12N2320/13 ,  C12N2320/30 ,  C12N2330/30 ,  G01N33/57492 ,  G01N2333/91205

Abstract: Monomeric and multimeric aptamers are provided. Also provided are pharmaceutical compositions which comprise same and methods of using same.

Abstract translation: 提供了单体和多聚体适体。 还提供了包含其的药物组合物和使用它们的方法。

公开(公告)号：US20180208674A1

公开(公告)日：2018-07-26

申请号：US15935010

申请日：2018-03-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef YARDEN ,  Michael SELA ,  Ruth MARON ,  FERRARO Daniela Aleida

IPC: C07K16/32 ,  A61K45/06 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/32 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/507 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77

Abstract: A method of treating triple negative breast cancer in a subject comprising administering to the subject a therapeutically effective amount of a combination of at least two anti epidermal growth factor receptor (EGF-R) antibodies exhibiting binding to different epitopes on the EGF-R, thereby treating triple negative breast cancer.