公开(公告)号：US20170210823A1

公开(公告)日：2017-07-27

申请号：US15328036

申请日：2014-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Moran GROSSMAN ,  Nir BEN-CHETRIT

IPC: C07K16/40 ,  A61K45/06 ,  A61K33/24 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K33/24 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

Abstract: An article of manufacture is disclosed which comprises at least two active agents, wherein a first of the two active agents comprises an anti-cancer agent or an antifibrotic agent and a second of the at least two active agents downregulates the activity and/or expression of lysyl-oxidase like protein-2 (LOXL-2) and which is capable of altering the structure of the extracellular matrix.