公开(公告)号：US20170210823A1

公开(公告)日：2017-07-27

申请号：US15328036

申请日：2014-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Moran GROSSMAN ,  Nir BEN-CHETRIT

IPC: C07K16/40 ,  A61K45/06 ,  A61K33/24 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K33/24 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

Abstract: An article of manufacture is disclosed which comprises at least two active agents, wherein a first of the two active agents comprises an anti-cancer agent or an antifibrotic agent and a second of the at least two active agents downregulates the activity and/or expression of lysyl-oxidase like protein-2 (LOXL-2) and which is capable of altering the structure of the extracellular matrix.

公开(公告)号：US20170165285A1

公开(公告)日：2017-06-15

申请号：US15438806

申请日：2017-02-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef YARDEN ,  Nir BEN-CHETRIT

IPC: A61K31/7048 ,  C07K16/30 ,  A61K31/366 ,  A61K31/7034 ,  A61K31/353 ,  A61K31/05 ,  A61K31/12 ,  A61K31/7032 ,  A61K31/155 ,  A61K31/4709 ,  A61K31/216 ,  A61K31/235 ,  A61K38/17 ,  A61K31/704

CPC classification number: A61K31/7048 ,  A61K31/05 ,  A61K31/12 ,  A61K31/155 ,  A61K31/216 ,  A61K31/235 ,  A61K31/353 ,  A61K31/366 ,  A61K31/4709 ,  A61K31/7032 ,  A61K31/7034 ,  A61K31/704 ,  A61K38/179 ,  A61K39/0011 ,  A61K45/06 ,  C07K16/30 ,  G01N33/57415 ,  A61K2300/00

Abstract: A method of preventing tumor metastasis with the proviso that the tumor is not glioma is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2), thereby preventing tumor metastasis. Also, provided is a method of treating cancer. The method comprising, administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2) and an inhibitor of a cell surface receptor associated with an onset or progression of cancer, thereby treating cancer.

公开(公告)号：US20170042857A1

公开(公告)日：2017-02-16

申请号：US15100322

申请日：2014-11-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Yosef YARDEN ,  Nir BEN-CHETRIT

IPC: A61K31/353 ,  A61K31/7048 ,  A61K31/7024 ,  A61K31/12 ,  A61K45/06 ,  A61K31/155 ,  A61K31/4709 ,  A61K31/216 ,  A61K31/235 ,  A61K31/05 ,  A61K31/7028 ,  A61K31/7032

CPC classification number: A61K31/353 ,  A61K31/05 ,  A61K31/12 ,  A61K31/155 ,  A61K31/216 ,  A61K31/235 ,  A61K31/4709 ,  A61K31/7024 ,  A61K31/7028 ,  A61K31/7032 ,  A61K31/704 ,  A61K31/7048 ,  A61K45/06

Abstract: Disclosed herein are synaptojanin-2 inhibitors, and novel methods and uses utilizing same for preventing tumor metastasis, treating cancer or inhibiting synaptojanin-2. Compounds disclosed herein include chlorhexidine and pyrvinium, the compound having the formula: and compounds characterized by the general formula: X-L-[(Y)i-(Z)j]-(L-X)k and/or by the general formula: wherein L, X, Y, Z, D, E, i, j and k are as defined herein.

Abstract translation: 其中L，X，Y，Z，D，E，i，j和k如本文所定义。