公开(公告)号：US20240228976A1

公开(公告)日：2024-07-11

申请号：US18421666

申请日：2024-01-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ravid Straussman ,  Nancy Gavert

IPC: C12N5/09 ,  A61K31/138 ,  A61K31/337 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/4748 ,  A61K31/502 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/243 ,  A61P35/00 ,  C12M1/12 ,  G01N33/50

CPC classification number: C12N5/0693 ,  A61K31/138 ,  A61K31/337 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/4748 ,  A61K31/502 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/243 ,  A61P35/00 ,  C12M25/00 ,  G01N33/5011 ,  C12N2503/02 ,  C12N2503/04 ,  C12N2513/00

Abstract: Ex-vivo culture systems are provided. Accordingly there is provided a culture system comprising a culture medium and a precision-cut tissue slice placed on a tissue culture insert, wherein the precision-cut tissue slice is maintained in a highly oxygenated atmosphere containing at least 50% oxygen and wherein said culture is rotationally agitated facilitating intermittent submersion of the tissue slice in the culture medium. Also provided are methods of culturing a tissue and methods of using the culture system for selecting a drug for the treatment of a disease.

公开(公告)号：US11920162B2

公开(公告)日：2024-03-05

申请号：US16499333

申请日：2018-04-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ravid Straussman ,  Nancy Gavert

IPC: A61K9/20 ,  A61K31/138 ,  A61K31/337 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/4748 ,  A61K31/502 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/243 ,  A61L27/26 ,  A61L27/54 ,  A61L27/58 ,  A61P35/00 ,  C12M1/12 ,  C12N5/0775 ,  C12N5/09 ,  G01N33/50

CPC classification number: C12N5/0693 ,  A61K31/138 ,  A61K31/337 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/4748 ,  A61K31/502 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/243 ,  A61P35/00 ,  C12M25/00 ,  G01N33/5011 ,  C12N2503/02 ,  C12N2503/04 ,  C12N2513/00

Abstract: Ex-vivo culture systems are provided. Accordingly there is provided a culture system comprising a culture medium and a precision-cut tissue slice placed on a tissue culture insert, wherein the precision-cut tissue slice is maintained in a highly oxygenated atmosphere containing at least 50% oxygen and wherein said culture is rotationally agitated facilitating intermittent submersion of the tissue slice in the culture medium. Also provided are methods of culturing a tissue and methods of using the culture system for selecting a drug for the treatment of a disease.