公开(公告)号：US20210315983A1

公开(公告)日：2021-10-14

申请号：US17092386

申请日：2019-05-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Yochai WOLF ,  Osnat BARTOK

IPC: A61K39/00 ,  A61P35/00 ,  C12N5/09 ,  G01N33/574

Abstract: A method of identifying a neoantigen in a tumor of a subject is disclosed. The method comprises:
(a) culturing cells of the tumor under conditions which generate single cell clones of the tumor; and
(b) analyzing the single cell clones for expression of a neoantigen which is reactive with T cells from the subject, thereby identifying the neoantigen in a tumor of a subject.