公开(公告)号：US09567371B2

公开(公告)日：2017-02-14

申请号：US14880238

申请日：2015-10-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Tsvee Lapidot ,  Alexander Kalinkovich ,  Matityahu Fridkin

IPC: C07K7/52 ,  A61K38/12 ,  A61K38/17 ,  C07K14/47 ,  A61K38/00

CPC classification number: A61K38/1729 ,  A61K38/00 ,  A61K38/12 ,  A61K38/193 ,  C07K7/52 ,  C07K14/4723

Abstract: The invention is directed to β-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer.

Abstract translation: 本发明涉及β-防御素衍生的肽及其在调节造血细胞，特别是造血干细胞和祖细胞活性中的用途。 具体地，本发明提供了有助于促进造血干细胞和祖细胞的移动和移植的组合物和方法。 本发明还提供了可用于治疗癌症的组合物和方法。