公开(公告)号：US20240043500A1

公开(公告)日：2024-02-08

申请号：US18483108

申请日：2023-10-09

Applicant: COLZYX AB

Inventor： Matthias MÖRGELIN ,  Suado ABDILLAHI

IPC: C07K14/78 ,  A61L27/54 ,  A61L15/44 ,  C07K14/47 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L17/00 ,  A61L17/14 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755

CPC classification number: C07K14/78 ,  A61L27/54 ,  A61L15/44 ,  C07K14/4723 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L15/325 ,  A61L17/005 ,  A61L17/145 ,  A61L24/0015 ,  A61L24/102 ,  A61L24/108 ,  A61L27/227 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/045 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/044 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755 ,  A61L2300/404 ,  A61K9/7023

Abstract: The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.

公开(公告)号：US11884710B2

公开(公告)日：2024-01-30

申请号：US17532307

申请日：2021-11-22

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Heloise Anne Pereira ,  Anne Kasus-Jacobi ,  Gina L. Griffith

IPC: A61K38/17 ,  C07K14/47 ,  A61K45/06 ,  A61K38/00

CPC classification number: C07K14/4723 ,  A61K38/17 ,  A61K38/1729 ,  A61K45/06 ,  A61K38/00 ,  Y02A50/30

Abstract: Peptide compounds and compositions containing the peptide compounds and methods for treating various infections, wounds, and skin conditions such as atopic dermatitis. Examples of wounds that may be treated include surface wounds such as lacerations, abrasions, avulsions, incisions, and amputations, pressure sores, bed sores, wounds due to peripheral vascular disease, post-surgical wounds, diabetic ulcers and wounds, burns, ocular wounds and abrasions, ocular ulcers, and treatment of inflammatory conditions such as dry eye. The peptide compounds and compositions may be used as treatments to enhance acceptance of grafts such as skin grafts and organ grafts.

公开(公告)号：US20230365639A1

公开(公告)日：2023-11-16

申请号：US18044802

申请日：2021-09-14

Applicant: AESCULUS BIO APS

Inventor： Jan Wehkamp ,  Louis Köninger

IPC: C07K14/47 ,  A61K47/54 ,  A61P31/00 ,  A61K47/65 ,  A61K47/10 ,  A61K47/26

CPC classification number: C07K14/4723 ,  A61K47/542 ,  A61P31/00 ,  A61K47/65 ,  A61K47/10 ,  A61K47/26

Abstract: The present invention relates to development of innovative antibiotics against drug resistant bacteria, viruses, protozoa, fungi or worms based on coupling of lipopeptides to fragments of human defensins to achieve high antimicrobial efficacy and biofilm degradation as well as low development of resistance while preserving the natural microbiota thus not only eradicating bacterial, viral, protozoal, fungal or worm infection but preventing a number of disorders associated with antibiotic treatment e.g. infection with C. difficile'.

公开(公告)号：US11814422B2

公开(公告)日：2023-11-14

申请号：US17474434

申请日：2021-09-14

Applicant: COLZYX AB

Inventor： Matthias Mörgelin ,  Suado Abdillahi

IPC: C07K14/78 ,  A61L27/54 ,  A61K38/00 ,  A61L15/44 ,  C07K14/47 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L17/00 ,  A61L17/14 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755 ,  A61K9/70 ,  A61K9/00

CPC classification number: C07K14/78 ,  A01N47/44 ,  A61L15/32 ,  A61L15/325 ,  A61L15/44 ,  A61L17/005 ,  A61L17/145 ,  A61L24/0015 ,  A61L24/102 ,  A61L24/108 ,  A61L27/227 ,  A61L27/24 ,  A61L27/34 ,  A61L27/54 ,  A61L27/60 ,  A61L29/045 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/044 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  A61P17/02 ,  A61P31/04 ,  C07K14/4723 ,  C07K14/755 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/7023 ,  A61K38/00 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/00 ,  A61L2430/34 ,  C07K2319/00

Abstract: The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.

公开(公告)号：US11807672B2

公开(公告)日：2023-11-07

申请号：US17062622

申请日：2020-10-04

Applicant: SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.

Inventor： Liping Liu ,  Ru Bai

IPC: C07K14/47 ,  A61K38/26 ,  A61K35/39 ,  A61K38/00 ,  C12N5/071

CPC classification number: C07K14/4705 ,  A61K35/39 ,  A61K38/26 ,  C07K14/4723 ,  C07K14/4726 ,  C12N5/0676 ,  A61K38/00 ,  C07K2319/30 ,  C12N2501/335 ,  C12N2501/998

Abstract: The invention provides novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and conditions, particularly diseases and conditions relating to diabetes. The compounds of the invention are also useful for treating impaired pancreatic function, treating metabolic diseases, ex vivo islet induction, expansion and proliferation for transplantation, increasing the survival of transplanted islets in vivo, promoting neuroprotection or nerve regeneration, promoting liver regeneration, and inhibiting inflammation.

公开(公告)号：US20190218538A1

公开(公告)日：2019-07-18

申请号：US16260407

申请日：2019-01-29

Applicant: LYSANDO AG

Inventor： Stefan MILLER

IPC: C12N9/52 ,  C07K14/47 ,  C12N9/36

CPC classification number: C12N9/52 ,  A61K38/00 ,  C07K14/4723 ,  C07K2319/035 ,  C07K2319/33 ,  C07K2319/50 ,  C12N9/2462

Abstract: The present invention relates to antimicrobial agents against Gram-positive bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-positive bacteria and an additional peptide stretch fused to the enzyme at the N- or C-terminus. Moreover, the present invention relates to nucleic acid molecules encoding said fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-positive bacterial infections, as diagnostic means or as cosmetic substance. The present invention also relates to the treatment or prevention of Gram-positive bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries. Further, the present invention relates to a pharmaceutical composition comprising said fusion protein.

公开(公告)号：US20190194246A1

公开(公告)日：2019-06-27

申请号：US16143917

申请日：2018-09-27

Applicant: CEM Corporation

Inventor： JONATHAN M. COLLINS

IPC: C07K1/04 ,  C07K1/06 ,  C07K1/14 ,  C07K7/08 ,  C07K7/16 ,  C07K14/005 ,  C07K14/46 ,  C07K14/47 ,  C07K14/575 ,  C07K14/59 ,  C07K14/605 ,  C07K14/635 ,  C07K14/645 ,  C07K14/705 ,  C07K14/815 ,  C07K1/107 ,  C12N7/00 ,  B01J19/12

CPC classification number: C07K1/045 ,  B01J19/126 ,  B01J2204/005 ,  B01J2219/00058 ,  B01J2219/0879 ,  B01J2219/1248 ,  C07K1/04 ,  C07K1/063 ,  C07K1/1075 ,  C07K1/14 ,  C07K7/08 ,  C07K7/16 ,  C07K14/005 ,  C07K14/463 ,  C07K14/4701 ,  C07K14/4723 ,  C07K14/575 ,  C07K14/57572 ,  C07K14/59 ,  C07K14/605 ,  C07K14/635 ,  C07K14/645 ,  C07K14/705 ,  C07K14/815 ,  C12N7/00 ,  C12N2740/16322

Abstract: An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.

公开(公告)号：US20180193411A1

公开(公告)日：2018-07-12

申请号：US15740480

申请日：2016-06-29

Applicant: Chain Antimicrobials Oy

Inventor： Tejesvi Mysore Vishakante Gowda ,  Anna Maria Pirttilä

IPC: A61K38/16 ,  C07K14/415 ,  A61P31/04 ,  A61P31/10

CPC classification number: A61K38/168 ,  A61P31/04 ,  A61P31/10 ,  C07K14/415 ,  C07K14/4723

Abstract: The present invention relates to novel antimicrobial peptide and variants thereof. The invention further relates to method of killing or inhibiting growth of microbes and use of the peptide here disclosed as a medicament, feed additive, preservative or surfactant.

公开(公告)号：US20180148489A2

公开(公告)日：2018-05-31

申请号：US15100213

申请日：2014-11-27

Applicant: University of Manitoba

Inventor： Neeloffer Mookherjee ,  Hadeesha Piyadasa

IPC: C07K14/47 ,  C07K7/08

CPC classification number: C07K14/4723 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08

Abstract: A composition for treating or preventing a Th2-dysregulated inflammatory condition wherein the composition comprises a therapeutically effective amount of one or more IDR peptides. Use of IDR peptides or a composition comprising IDR peptides for treating or preventing a Th2-dysregulated inflammatory condition. The Th2-dysregulated inflammatory condition includes allergy or atopy, for example allergic asthma.

公开(公告)号：US20180141987A1

公开(公告)日：2018-05-24

申请号：US15503899

申请日：2015-08-13

Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

Inventor： Shuchishweta Vinay KENDURKAR ,  Durba SENGUPTA

IPC: C07K14/47 ,  A61K38/08 ,  C07K7/08 ,  A61K38/10

CPC classification number: C07K14/4723 ,  A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  Y02A50/473 ,  Y02A50/481

Abstract: The present invention provides anti-microbial compositions comprising synthetic peptides for therapeutic use. These compositions have found applications in treating human and plant infections.