公开(公告)号：US20230272484A1

公开(公告)日：2023-08-31

申请号：US18142618

申请日：2023-05-03

Applicant: Yeda Research and Development Co. Ltd. ,  Ichilov Tech Ltd.

Inventor： Ido AMIT ,  Assaf WEINER ,  Mor ZADA ,  Chamutal BORNSTEIN-OVITS ,  Shuang-Yin WANG ,  Yael COHEN

IPC: C12Q1/6886 ,  A61K38/07 ,  A61K31/69 ,  A61K38/13 ,  A61K31/7076 ,  A61P35/00

CPC classification number: C12Q1/6886 ,  A61K38/07 ,  A61K31/69 ,  A61K38/13 ,  A61K31/7076 ,  A61P35/00 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: A method of prognosing a subject diagnosed with multiple myeloma (MM) is provided. Also provided a method of treating a subject diagnosed with MM selected expressing intracellular PPIA and/or RRM2 above a predetermined threshold, the method comprising administering to the subject a therapeutically effective amount of at least one agent which specifically down-regulates activity or expression of PPIA and/or RRM2, thereby treating the subject.