公开(公告)号：US20240060965A1

公开(公告)日：2024-02-22

申请号：US18235922

申请日：2023-08-21

Applicant: ICHILOV TECH LTD. ,  SCOPIO LABS LTD.

Inventor： Benzi KATZ ,  Irit AVIV ,  Shahar KARNY ,  Hadar SHIMONI ,  Amit NATAN ,  Ofek AIZENMAN

IPC: G01N33/50 ,  G01N1/30

CPC classification number: G01N33/5094 ,  G01N1/30 ,  G01N2800/52

Abstract: Methods of predicting the response of a subject to chimeric antigen receptor (CAR) therapy comprising receiving peripheral blood smears (PBS) from the subject and determining the number of CAR cells in the PBS are provided.

公开(公告)号：US20240043555A1

公开(公告)日：2024-02-08

申请号：US18229821

申请日：2023-08-03

Applicant: ICHILOV TECH LTD.

Inventor： Idit F. SCHWARTZ ,  Nadir ARBER ,  Doron SCHWARTZ ,  Lior YANKELSON

IPC: C07K16/28 ,  A61K31/7105 ,  A61P13/12

CPC classification number: C07K16/2896 ,  A61K31/7105 ,  A61P13/12 ,  C07K2317/76

Abstract: Provided herein is a method for treating or preventing a kidney disease or injury in a subject in need thereof, the method including administering to the subject a therapeutically effective amount of pharmaceutical composition including a CD24 inhibitor. Further provided is a method for inhibiting a damage associated molecular pattern (DAMP) in a subject, including administering to the subject a therapeutically effective amount of pharmaceutical composition including a CD24 inhibitor.

公开(公告)号：US20230084299A1

公开(公告)日：2023-03-16

申请号：US17799920

申请日：2021-02-17

Applicant: ICHILOV TECH LTD.

Inventor： Einor Ben Assayag

IPC: A61K31/439 ,  A61K31/343 ,  A61K31/135 ,  A61K31/55 ,  A61P25/28

Abstract: The invention relates to the treatment of depressive and anxiety disorders, specifically to improved therapy for patients afflicted with post-stroke depression and/or anxiety, or with major depressive disorder. More specifically, the invention relates to the use of chemokine receptor (CCR5) inhibitors, either alone or in combination with antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), in treating depression and anxiety, as well as certain post-stroke complications that may include cognitive impairment. Compositions and methods according to embodiments of the invention are advantageously useful in the treatment of patients with treatment-resistant depression and other patient populations in which conventional antidepressant therapy is inadequate or insufficient.

公开(公告)号：US20230058044A1

公开(公告)日：2023-02-23

申请号：US17779704

申请日：2020-11-25

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  ICHILOV TECH LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Vered PADLER-KARAVANI ,  Yafit ATIYA-NASAGI ,  Ron AMON ,  Anat GLOBERSON LEVIN ,  Tova WAKS ,  Moran RAWET-SLOBODKIN ,  Lihi NINIO MANY ,  Zelig ESHHAR

IPC: A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K14/735 ,  C12N5/0783

Abstract: The present invention discloses chimeric antigen receptors that specifically recognize and bind to SLe A carbohydrate antigen with high specificity and selectivity. The invention further provides lymphocytic cells, such as T cells, comprising said CARs, compositions comprising said cells or CARs as well as uses thereof.

公开(公告)号：US20210322483A1

公开(公告)日：2021-10-21

申请号：US17186039

申请日：2021-02-26

Applicant: Ichilov Tech Ltd.

Inventor： Nadir ARBER ,  Shiran SHAPIRA

IPC: A61K35/33 ,  A61P37/06 ,  A61K38/17 ,  A61P31/14 ,  C12N5/077 ,  A61P11/00 ,  A61K9/00 ,  A61K9/127

Abstract: A composition comprising cell-derived particles presenting heterologous CD24, wherein the cell is a non-cancerous cell and wherein the composition is substantially devoid of intact cells is disclosed. Methods of producing the cell-derived particles and methods of using the cell-derived particles in treatment of cytokine storm syndrome, tissue injury associated with the inflammation and Coronavirus infection are also disclosed.

公开(公告)号：US12227766B2

公开(公告)日：2025-02-18

申请号：US18224131

申请日：2023-07-20

Applicant: Ichilov Tech Ltd.

Inventor： Nadir Arber ,  Shiran Shapira

IPC: C07K14/705 ,  C07K14/71 ,  C12N5/00 ,  C12N5/071 ,  C12N5/077

Abstract: A method of producing cell derived particles is disclosed. The method comprising isolating cell-derived particles from a biological sample comprising cells modified to present CD24 so as to obtain a preparation of the cell-derived particles substantially devoid of intact cells. Cell derived particles, a culture medium and a cell culture are also disclosed.

公开(公告)号：US12171568B2

公开(公告)日：2024-12-24

申请号：US17435906

申请日：2020-03-03

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  ICHILOV TECH LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Talma Hendler ,  Asya Rolls ,  Nitzan Lubianiker ,  Tamar Koren ,  Neomi Singer ,  Tamar Ben Shannan ,  Shai Shen Orr ,  Fahed Hakim ,  Hilla Azulay-Debby ,  Rani Cohen

IPC: A61B5/00 ,  A61B5/055 ,  A61B5/378 ,  A61B10/00

Abstract: The present invention is directed to a method for inducing an immune response in a subject, including a step of activating neurons in the mesolimbic network of the subject by applying a neurofeedback.

公开(公告)号：US20230167158A1

公开(公告)日：2023-06-01

申请号：US18096167

申请日：2023-01-12

Applicant: ICHILOV TECH LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Amer M NAJJAR ,  Anat GLOBERSON LEVIN ,  Tova WAKS ,  Galit HORN

IPC: C07K14/005 ,  C07K16/28 ,  C07K14/705 ,  A61P35/00

CPC classification number: C07K14/005 ,  C07K16/2809 ,  C07K14/70517 ,  A61P35/00 ,  C12N2760/20023 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2760/20222 ,  C12N2760/20242 ,  C12N2760/20271 ,  A61K2039/505

Abstract: The present invention discloses a fusion protein comprising a vesicular stomatitis virus envelope glycoprotein (VSVG) extracellular domain or a fragment or an analog thereof linked to a polypeptide comprising an antigen binding domain specific to cluster of differentiation 3 (CD3). The application also discloses pseudotyped viruses comprising the fusion protein and pseudotyped viruses encoding for a chimeric antigen receptor (CAR) or T-cell receptor pseudotyped in which the receptor is expressed under a CD3 promoter. Pseudotyped viruses combining these properties are encompassed as well. The application further discloses use of these pseudotyped viruses and method of producing these pseudotyped viruses.

公开(公告)号：US20230003742A1

公开(公告)日：2023-01-05

申请号：US17781706

申请日：2020-12-10

Applicant: ICHILOV TECH LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Shani Shenhar-Tsarfaty ,  Shlomo Avraham Berliner ,  Ori Rogowski ,  Eyal Fisher ,  Adi Silberman ,  Yishai Levin

IPC: G01N33/68

Abstract: The invention provides assays and methods for detecting and monitoring systemic inflammation Particularly, the invention in embodiments thereof relates to the use of urinary biomarkers for non-invasive determination of the level of inflammation.

公开(公告)号：US20220370517A1

公开(公告)日：2022-11-24

申请号：US17854034

申请日：2022-06-30

Applicant: Ichilov Tech Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Jacob MASHIAH ,  Nitsan MAHARSHAK

IPC: A61K35/741 ,  A61K35/745 ,  A61K35/742 ,  A61K35/24 ,  A61P17/00

Abstract: A method of treating atopic dermatitis (AD) in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of at least two species of bacteria.