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    ICAM-1 TARGETED FUSION ENZYMES
    91.
    发明申请
    ICAM-1 TARGETED FUSION ENZYMES 有权

    公开(公告)号：US20210147495A1

    公开(公告)日：2021-05-20

    申请号：US16951774

    申请日：2020-11-18

    申请人： University of Maryland, College Park

    发明人： Silvia Muro ,  Jing Chen ,  Melani Solomon ,  Kevin Gray

    IPC分类号： C07K14/47 ,  C12N9/16 ,  C12N9/40 ,  C12N9/24

    摘要： Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided. The described proteins can be used as a protein therapy, a gene therapy, or an implanted cell therapy.

    Device and method to transform discrete voltage pulses to a phase-sensitive continuous signal
    93.
    发明授权
    Device and method to transform discrete voltage pulses to a phase-sensitive continuous signal 有权

    公开(公告)号：US10999109B2

    公开(公告)日：2021-05-04

    申请号：US16519755

    申请日：2019-07-23

    申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK ,  NATIONAL INSTITUTE OF STANDARDS & TECHNOLOGY

    发明人： Kapildeb Ambal ,  Robert D. McMichael

    IPC分类号： H04L27/06 ,  H04L27/14 ,  H04B1/16

    摘要： Systems, methods, and apparatuses, for transform discrete voltage pulses to a continuous signal. One method may include receiving a pulsed-voltage signal. The method may also include alternately directing the pulsed-voltage signal between a pair of processing channels based on a modulation signal or another signal. The method may further include determining rate voltages corresponding to the pair of processing channels based on a pulse rate of the pulsed-voltage signal. Further, the method may include processing the rate voltages using low pass filters corresponding to the pair of processing channels to form filtered rate voltages. The method may also include determining a normalized differential output for the pair of processing channels based on the filtered rate voltages. The method may also include outputting the normalized differential output to an output connector.

    TRANSPARENT WOOD COMPOSITE, SYSTEMS AND METHOD OF FABRICATION
    94.
    发明申请
    TRANSPARENT WOOD COMPOSITE, SYSTEMS AND METHOD OF FABRICATION 有权

    公开(公告)号：US20210122902A1

    公开(公告)日：2021-04-29

    申请号：US16074148

    申请日：2017-02-03

    申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK

    发明人： LIANGBING HU ,  MINGWEI ZHU ,  TIAN LI ,  AMY S. GONG ,  JIANWEI SONG

    IPC分类号： C08L1/02 ,  H01L31/0216 ,  H01L31/0304 ,  H01L31/18 ,  B27K3/02 ,  B27K3/15 ,  C08J9/42 ,  C08J9/26

    摘要： Highly transparent (up to 92% light transmittance) wood composites have been developed. The process of fabricating the transparent wood composites includes lignin removal followed by index-matching polymer infiltration resulted in fabrication of the transparent wood composites with preserved naturally aligned nanoscale fibers. The thickness of the transparent wood composite can be tailored by controlling the thickness of the initial wood substrate. The optical transmittance can be tailored by selecting infiltrating polymers with different refractive indices. The transparent wood composites have a range of applications in biodegradable electronics, optoelectronics, as well as structural and energy efficient building materials. By coating the transparent wood composite layer on the surface of GaAs thin film solar cell, an 18% enhancement in the overall energy conversion efficiency has been attained.

    Methods and arrangements to enhance optical signals within aberrated or scattering samples
    95.
    发明授权
    Methods and arrangements to enhance optical signals within aberrated or scattering samples 有权

    公开(公告)号：US10989591B2

    公开(公告)日：2021-04-27

    申请号：US16785123

    申请日：2020-02-07

    申请人： University of Maryland, College Park

    发明人： Giuliano Scarcelli ,  Eitan Edrei

    IPC分类号： G01J3/44 ,  G01J3/02 ,  G01N21/65 ,  G01N21/63 ,  G01N21/64

    摘要： An optical system has an illumination optical assembly, a detection optical assembly, a wavefront shaping device, and a controller. The illumination optical assembly focuses interrogating optical radiation to a focal point on or in a sample. The interrogating optical radiation propagates to the focal point along a first optical axis. The detection optical assembly direct optical radiation emanating from the focal point to a detector. The emanating optical radiation propagates from the focal point along a second optical axis. The wavefront shaping device is disposed in an optical path of the interrogating optical radiation or in an optical path of the emanating optical radiation. The controller sets a configuration of the wavefront shaping device to correct for aberration. The first optical axis is at a non-zero angle with respect to the second optical axis.

    Laser cavity optical alignment
    100.
    发明授权
    Laser cavity optical alignment 有权

    公开(公告)号：US10910786B2

    公开(公告)日：2021-02-02

    申请号：US16506873

    申请日：2019-07-09

    申请人： University of Maryland, College park ,  IonQ, Inc.

    发明人： Kai Hudek

    IPC分类号： H01S3/02 ,  G02B27/10 ,  H01S3/00 ,  H01S3/10

    摘要： The disclosure describes aspects of laser cavity optical alignment, and more particularly, in situ alignment of optical devices in an optical system for replacement or upgrade. In one aspect, a method for optical alignment in an optical system is described that includes providing, via a positioning system, an optical beam to measure surface features and position of a first device under test (DUT), removing the first DUT from the optical system, placing a second DUT in the optical system at substantially the same position from which the first DUT was removed, providing, via the positioning system, an optical beam to measure surface features and position of the second DUT, aligning the second DUT based on the measurements made of the first DUT and the second DUT, and verifying operation of the second DUT in the optical system. The DUT can be an optical device such as an output optical coupler.