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294 条记录 (耗时 0.032 秒)

    Dimeric Azacyclic Compounds and Their Use
    91.
    发明申请
    Dimeric Azacyclic Compounds and Their Use 失效
    二甲基偶氮化合物及其用途

    公开(公告)号：US20080242668A1

    公开(公告)日：2008-10-02

    申请号：US10586838

    申请日：2005-02-01

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B. Timmermann

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B. Timmermann

    IPC分类号： A61K31/498 ,  C07D221/02 ,  A61K31/4375 ,  A61P9/00 ,  A61P29/00 ,  A61P25/00 ,  C07D403/02

    摘要： This invention relates to azacyclic derivatives according of formula (I) and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or. disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the′ termination of abuse of chemical substances. Formula (I) Aza-X′-A′-Y′-L-Y-A″-X″-Aza Aza:Azabicyclic group A′,A″:Aromatic monocyclic and/or polycyclic, carbocyclic and/or heterocyclic group Y′,Y″: Linker or absent (covalent bond) L: Monocyclic or polycyclic, carbocyclic or heterocyclic group or is absent X′,X″: Linker or absent (covalent bond)

    摘要翻译： 本发明涉及式（I）的氮杂环十二烷基衍生物及其作为药物的用途。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或疾病，疾病或。 与“终止化学物质的滥用”引起的与炎症，疼痛和戒断症状有关的神经变性，疾病或病症相关的疾病。 式（I）Aza-X'-A'-Y'-LY-A“-X” - 氮杂氮杂：氮杂双环基A'，A“：芳族单环和/或多环，碳环和/或杂环基 Y'，Y“：连接体或不存在（共价键）L：单环或多环，碳环或杂环基团或不存在X'，X”：连接基或不存在（共价键）

    NOVEL COMPOUNDS
    94.
    发明申请
    NOVEL COMPOUNDS 审中-公开
    新型化合物

    公开(公告)号：US20120004257A1

    公开(公告)日：2012-01-05

    申请号：US13173178

    申请日：2011-06-30

    申请人： Dan Peters ,  Gordon Munro ,  Elsebet Østergaard Nielsen

    发明人： Dan Peters ,  Gordon Munro ,  Elsebet Østergaard Nielsen

    IPC分类号： A61K31/46 ,  A61P25/04 ,  A61P25/24 ,  C07D451/06 ,  A61P25/00

    CPC分类号： C07D451/06

    摘要： The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

    摘要翻译： 本申请公开了新颖的8-氮杂 - 双环[3.2.1]辛-3-基氧基）色烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途。 在其它方面，申请公开了这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

    NOVEL 4-BENZHYDRYLOXY-TETRAALKYL-PIPERIDINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
    95.
    发明申请
    NOVEL 4-BENZHYDRYLOXY-TETRAALKYL-PIPERIDINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开
    新型4-苄氧基 - 四氢吡啶衍生物及其作为单胺神经递质抑制剂的用途

    公开(公告)号：US20110053984A1

    公开(公告)日：2011-03-03

    申请号：US12921030

    申请日：2009-02-27

    申请人： Dan Peters ,  John Paul Redrobe ,  Elsebet Østergaard Nielsen

    发明人： Dan Peters ,  John Paul Redrobe ,  Elsebet Østergaard Nielsen

    IPC分类号： A61K31/445 ,  C07D211/46 ,  A61P25/00 ,  A61P29/00 ,  A61P13/00 ,  A61P15/00

    CPC分类号： C07D211/46

    摘要： This invention relates to novel 4-benzhydryloxy-tetraalkyl-piperidine derivatives of Formula (I), any of its stereoisomers or any mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein Ra represents hydrogen or C1-6-alkyl; Rb and Rc independent of each other represent a phenyl group, which phenyl group is optionally substituted with one or more substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, C1-6-alkoxy and methylenedioxo; R′, R″, R′″ and R″″ independent of each other represent C1-6-alkyl; and with the proviso that the compound is not 4-benzhydryloxy-1,2,2,6,6-pentamethyl-piperidine, useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

    摘要翻译： 本发明涉及式（I）的新型4-二苯甲氧基 - 四烷基 - 哌啶衍生物，其任何立体异构体或其立体异构体的任何混合物或其N-氧化物或其药学上可接受的盐，其中R a表示氢或C 1 -6-烷基; Rb和Rc彼此独立地表示苯基，该苯基任选被一个或多个独立地选自卤素，三氟甲基，三氟甲氧基，氰基，C 1-6 - 烷氧基和亚甲基二氧基的取代基取代; R'，R“，R”“和R”“彼此独立地表示C 1-6 - 烷基; 并且条件是该化合物不是4-二苯甲基氧基-1,2,2,6,6-五甲基哌啶，其可用作单胺神经递质再摄取抑制剂。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。