公开(公告)号：US5051412A

公开(公告)日：1991-09-24

申请号：US576429

申请日：1990-09-17

申请人： John E. Macor

发明人： John E. Macor

IPC分类号： A61K31/44 ,  A61K31/445 ,  A61P3/04 ,  A61P3/06 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D471/04

CPC分类号： C07D471/04

摘要： Compounds of the formula ##STR1## wherein one of A, B, D and E is N and the remaining three atoms are C; R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1 to C.sub.6 alkyl; and R.sup.3, R.sup.4, R.sup.5 and R.sub.6 are independently selected from hydrogen, halogen, hydroxy, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.8 alkoxy, phenyl-C.sub.1 -C.sub.6 alkoxy, phenoxy --NR.sup.7 R.sup.8 wherein R.sup.7 and R.sup.8 are independently selected from hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.6 alkanoyl and COOR.sup.9 wherein R.sup.9 is hydrogen or C.sub.1 -C.sub.6 alkyl, cyano, COOR.sup.10 wherein R.sup.10 is hydrogen or C.sub.1 -C.sub.6 alkyl, and CONR.sup.11 R.sup.12 where R.sup.10 and R.sup.11 are independently selected from hydrogen and C.sub.1 -C.sub.6 alkyl, and the pharmaceutically acceptable salts thereof. The compounds are useful psychotherapeutics and may be used in treating obesity, depression and disorders wherein aggression is a symptom.