公开(公告)号：US20030059484A1

公开(公告)日：2003-03-27

申请号：US10244741

申请日：2002-09-17

Applicant: LVMH RECHERCHE

Inventor： Frederic Bonte ,  Marc Dumas ,  Catherine Heusele ,  Jacques Le Blay

IPC: A61K035/78 ,  A61K031/195 ,  A61K033/14 ,  A61K031/4172 ,  A61K031/401 ,  A61K031/198

CPC classification number: C07K14/78 ,  A61K8/365 ,  A61K8/44 ,  A61K8/97 ,  A61K36/185 ,  A61K36/48 ,  A61K36/73 ,  A61K2800/58 ,  A61K2800/70 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q19/08 ,  Y10S514/847 ,  A61K2300/00

Abstract: The present invention relates to a method of cosmetic treatment for combating the effects of skin ageing and to novel cosmetic compositions which are particularly suitable for carrying it out. According to the invention, at least one agent for promoting the adhesion of the keratinocytes of the epidermal basal layer to the dermo-epidermal junction, especially to the collagen IV of said junction, such as, in particular, a divalent metal salt or complex, preferably magnesium aspartate or magnesium chloride, is used, optionally in association with a stimulant of collagen IV synthesis and/or a stimulant of collagen VII synthesis. Application: Preparation of cosmetic compositions with anti-wrinkle activity.

Abstract translation: 本发明涉及一种用于抵抗皮肤老化效果的美容治疗方法和特别适用于进行皮肤老化的新型化妆品组合物。 根据本发明，至少一种用于促进表皮基底层的角质形成细胞粘附到皮肤 - 表皮连接处，特别是所述连接处的胶原IV，特别是二价金属盐或复合物的粘附剂， 优选使用天冬氨酸镁或氯化镁，任选地与胶原IV合成的兴奋剂和/或胶原VII合成的兴奋剂结合。 应用：具有抗皱作用的化妆品组合物的制备。