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    Treatment of skin damage using acetyl carnitine and lipoic acid
    1.
    发明申请
    Treatment of skin damage using acetyl carnitine and lipoic acid 审中-公开
    使用乙酰肉碱和硫辛酸治疗皮肤损伤

    公开(公告)号：US20040265345A1

    公开(公告)日：2004-12-30

    申请号：US10609777

    申请日：2003-06-30

    发明人： Nicholas V. Perricone

    IPC分类号： A61K031/385 ,  A61K031/205 ,  A61K031/375 ,  A61K031/198

    CPC分类号： A61K31/385 ,  A61K31/198 ,  A61K31/205 ,  A61K31/375 ,  A61K2300/00

    摘要： A composition containing both acetyl carnitine and lipoic acid are topically applied to treat skin damage, such as contact dermatitis, atopic dermatitis, xerosis, eczema, rosacea, seborrhea, psoriasis, thermal and radiation burns, other types of skin inflammation, and aging. Typical compositions contain from about 0.025% to about 5%, more narrowly from about 0.5% to about 2% by weight acetyl carnitine, and from about 0.1% to about %, more narrowly from about 0.25% to about 5% lipoic acid or lipoic acid derivative in a dermatologically acceptable carrier that contains phosphatidylcholine. Many embodiments also contain at least one adjunct ingredient such as tyrosine, a fatty acid ester of ascorbic acid such as ascorbyl palmitate, a null-hydroxy acid such as glycolic acid, and/or folic acid. A preferred embodiment contains acetyl carnitine, lipoic acid, and tyrosine.

    摘要翻译： 局部施用含有乙酰肉碱和硫辛酸的组合物以治疗皮肤损伤，例如接触性皮炎，特应性皮炎，干燥症，湿疹，酒渣鼻，皮脂溢，牛皮癣，热和放射性灼伤，其他类型的皮肤炎症和衰老。 典型的组合物含有约0.025％至约5％，更窄的约0.5％至约2％的乙酰肉碱，和约0.1％至约％，更窄的约0.25％至约5％的硫辛酸或硫辛酸 含有磷脂酰胆碱的皮肤病学可接受的载体中的酸衍生物。 许多实施方案还含有至少一种辅助成分如酪氨酸，抗坏血酸的脂肪酸酯如棕榈酸抗坏血酸酯，α-羟基酸如乙醇酸和/或叶酸。 优选的实施方案包含乙酰肉碱，硫辛酸和酪氨酸。

    5-cnac as oral delivery agent for parathyroid hormone fragments
    3.
    发明申请
    5-cnac as oral delivery agent for parathyroid hormone fragments 审中-公开
    5-cnac作为甲状旁腺激素片段的口服递送剂

    公开(公告)号：US20040242478A1

    公开(公告)日：2004-12-02

    申请号：US10484331

    申请日：2004-06-03

    发明人： Moise Azria ,  Simon David Bateman

    IPC分类号： A61K038/29 ,  A61K031/198

    CPC分类号： A61K47/183 ,  A61K9/4858 ,  A61K31/198 ,  A61K38/29 ,  A61K2300/00

    摘要： Pharmaceutical compositions for the effective oral delivery of a parathyroid hormone, PTH, as well as methods for administration of the compositions are provided. Additionally, methods for stimulating new bone formation and treating and/or preventing osteoporosis are also provided.

    摘要翻译： 提供了用于有效口服递送甲状旁腺激素（PTH）的药物组合物，以及给药组合物的方法。 此外，还提供了刺激新骨形成和治疗和/或预防骨质疏松症的方法。

    Body temperature-raising agent of amino acids for eating or drinking and for medical use
    4.
    发明申请
    Body temperature-raising agent of amino acids for eating or drinking and for medical use 审中-公开
    用于饮食和医疗用途的氨基酸体温升高剂

    公开(公告)号：US20040235923A1

    公开(公告)日：2004-11-25

    申请号：US10479605

    申请日：2004-06-29

    发明人： Takashi Abe ,  Hajime Tsunoo ,  Masayuki Uchida ,  Takae Wakabayashi ,  Hiroshi Tsuchita

    IPC分类号： A61K031/4172 ,  A61K031/401 ,  A61K031/405 ,  A61K031/198

    CPC分类号： A61K31/4172 ,  A23L2/52 ,  A23L33/175 ,  A61K31/198 ,  A61K31/205 ,  A61K31/401 ,  A61K31/405 ,  A61K45/06

    摘要： The present invention forms a mixture basically consisting of threonine, proline, glycine, valine, isoleucine, leucine, tyrosine, phenylalanine, lysine, aspartic acid, serine, glutamic acid, alanine, methionine, histidine and arginine as a unit, by which a body temperature raising effect was observed. The similar body temperature raising effect was observed when carnitine and/or tryptophan is added to the unit. These groups were found to be amino acid mixture-containing agents capable of raising body temperature for food or drink use or medical use. The agents have excellent body temperature raising effect, thereby having the functions of reduction of accumulated body fat, alleviation of excess sensitivity to cold, warming of a cold body, and the like.

    摘要翻译： 本发明形成基本上由苏氨酸，脯氨酸，甘氨酸，缬氨酸，异亮氨酸，亮氨酸，酪氨酸，苯丙氨酸，赖氨酸，天冬氨酸，丝氨酸，谷氨酸，丙氨酸，甲硫氨酸，组氨酸和精氨酸为单位组成的混合物， 观察到升温效果。 当将肉碱和/或色氨酸加入到该单元中时，观察到类似的体温升高效应。 发现这些组是能够提高食物或饮料使用或医疗用途的体温的含氨基酸混合物的试剂。 这些药剂具有优异的体温提高效果，具有减少积累的身体脂肪，减轻对冷感过度敏感，冷身变暖等功能。

    Pharmaceutical composition for reducing vaginal acidity and treatment of vaginitis, and the use thereof
    6.
    发明申请
    Pharmaceutical composition for reducing vaginal acidity and treatment of vaginitis, and the use thereof 失效
    用于减少阴道酸度和治疗阴道炎的药物组合物及其用途

    公开(公告)号：US20040229822A1

    公开(公告)日：2004-11-18

    申请号：US10798072

    申请日：2004-03-11

    发明人： Zhongming Zeng

    IPC分类号： A61K038/04 ,  A61K031/496 ,  A61K031/4196 ,  A61K031/4172 ,  A61K031/198

    CPC分类号： A61K38/1709 ,  A61K31/198

    摘要： A composition is disclosed for treating a patient suffering from abnormally high acidity in the vagina, wherein the vaginal pH value is lower than 4.0. The composition consists essentially of: (a) an effective amount of the following amino acids and/or physiologically acceptable salts thereof: glutamic acid, aspartic acid, isoleucine, phenylalanine and praline; (b) an effective amount of anti-fungi drugs; and (c) a sufficient amount of pharmaceutically acceptable acid or alkali, which results in a pH of the composition from 4.0-8.0; (d). One or more pharmaceutical carriers is used for the composition. The composition is particularly useful for treating vaginitis and fungal vaginitis associated with abnormally high vaginal acidity of a pH value less than 4.0.

    摘要翻译： 公开了用于治疗阴道异常高酸度的患者的组合物，其中阴道pH值低于4.0。 组合物基本上由以下组成：（a）有效量的以下氨基酸和/或其生理上可接受的盐：谷氨酸，天冬氨酸，异亮氨酸，苯丙氨酸和果仁酸; （b）有效量的抗真菌药物; 和（c）足够量的药学上可接受的酸或碱，其导致组合物的pH为4.0-8.0; （d）。 一种或多种药物载体用于组合物。 该组合物特别可用于治疗与pH值小于4.0的异常高阴道酸度相关的阴道炎和真菌性阴道炎。

    Aqueous stable lysine solution
    8.
    发明申请
    Aqueous stable lysine solution 审中-公开
    水稳定赖氨酸溶液

    公开(公告)号：US20040214895A1

    公开(公告)日：2004-10-28

    申请号：US10849842

    申请日：2004-05-21

    申请人： Ajinomoto Co., Inc.

    发明人： Kazuhiro Hasegawa ,  Toshiya Tanabe ,  Keita Minami

    IPC分类号： A61K031/198 ,  C07C229/04

    CPC分类号： C07C229/26 ,  A23K20/142

    摘要： Herein is disclosed an aqueous stable lysine solution containing an acid radical in such amount that the solubility of lysine therein has been increased than in the corresponding aqueous lysine base solution, whereby during storage of lysine in the form of a free-lysine solution (liquid composition), the precipitation of lysine base crystals due to the drop in temperature is prevented thereby improving the handling thereof during transportation (transfer) etc.

    摘要翻译： 本文公开了含有酸度的含水稳定的赖氨酸溶液，其量使得其中的赖氨酸的溶解度比相应的赖氨酸赖氨酸碱溶液的溶解度增加，由此在游离赖氨酸溶液（液体组合物 ），防止了由于温度下降引起的赖氨酸碱晶体的沉淀，从而改善了在运输（转移）等过程中的处理。

    Method of treating a swollen gland curing cancer
    9.
    发明申请
    Method of treating a swollen gland curing cancer 审中-公开
    治疗肿胀腺癌治疗癌症的方法

    公开(公告)号：US20040204489A1

    公开(公告)日：2004-10-14

    申请号：US10414140

    申请日：2003-04-14

    发明人： Arthur Vanmoor

    IPC分类号： A61K031/198 ,  A61K031/195

    CPC分类号： A61K31/198 ,  A61K31/195 ,  A61K2300/00

    摘要： There is disclosed a method of treating a swollen gland in a person in need of such treatment, which comprises the administration to such person of an effective amount of at least one compound represented by formula (I) XnullCH2nullCH(OY)1-p(H)pCH(NH2null)pCOOnullnullnull(I) wherein X represents a trimethylammonio group (CH3)3Nnull or a carbamoyl group (CONH2), Y is hydrogen or an acetyl (CH3CO) group, and p is zero or one, provided that when X is a carbamoyl group p is one, and when X is a trimethylammonio group p is zero.

    摘要翻译： 公开了一种治疗需要这种治疗的人的肿胀腺的方法，其包括向该人施用有效量的由式（I）X-CH 2 -CH（OY）1表示的至少一种化合物 p（H）pCH（NH 2 +）p COO - （I）其中X表示三甲基铵基（CH 3）3 N +或氨基甲酰基（CONH 2），Y是氢或乙酰基（CH 3 CO） 是0或1，条件是当X是氨基甲酰基时，p是1，当X是三甲基铵基时，p是0。

    N-fatty acid-amino acid conjugates and therapeutic uses
    10.
    发明申请
    N-fatty acid-amino acid conjugates and therapeutic uses 审中-公开
    N-脂肪酸 - 氨基酸共轭物和治疗用途

    公开(公告)号：US20040197399A1

    公开(公告)日：2004-10-07

    申请号：US10747030

    申请日：2003-12-23

    申请人： University of Massachusetts, a Massachusetts corporation

    发明人： Sumner H. Burstein ,  Robert B. Zurier

    IPC分类号： A61K031/198 ,  A61K009/20

    CPC分类号： A61K31/198 ,  A61K31/20

    摘要： The present invention relates to the use of N-fatty acid-amino acid conjugates to treat, prevent, or manage tissue inflammation, leukocyte adhesion, or pain. The invention includes pharmaceutical compositions comprising N-fatty acid-amino acid conjugates and methods of administering N-fatty acid-amino acid conjugates and pharmaceutical compositions thereof as therapeutic agents.

    摘要翻译： 本发明涉及N-脂肪酸 - 氨基酸缀合物用于治疗，预防或治疗组织炎症，白细胞粘附或疼痛的用途。 本发明包括包含N-脂肪酸 - 氨基酸共轭物的药物组合物和施用N-脂肪酸 - 氨基酸缀合物的方法及其药物组合物作为治疗剂。