公开(公告)号：US20210078960A1

公开(公告)日：2021-03-18

申请号：US16772300

申请日：2018-12-17

申请人： MEDSHINE DISCOVERY INC.

发明人： Jianfei WANG ,  Yang ZHANG ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D249/12 ,  A61P19/06

摘要： Disclosed are a crystal of a 4-(naphthalene-1-yl)-4H-1,2,4-triazole compound (1) and a preparation method therefor, also comprised are applications of the crystal in preparing a medicament for treating an abnormal uric acid level-related disease.

公开(公告)号：US20210078958A1

公开(公告)日：2021-03-18

申请号：US16955510

申请日：2018-12-19

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X. CHEN ,  XiaWei WEI ,  Li ZHANG ,  Yanxin YU ,  Kai ZHOU ,  Boyu HU ,  Zhaoguo CHEN ,  Huiyu ZHANG ,  Shuhui CHEN

IPC分类号： C07D239/94 ,  C07D409/12 ,  C07D413/12 ,  C07D403/12 ,  C07D405/12 ,  C07D401/12 ,  C07D413/14 ,  C07D498/04 ,  C07D405/14 ,  C07D409/14

摘要： The present invention relates to a series of quinazoline compounds, especially compounds as represented by formula (I), isomers thereof or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and use thereof as Pan-HER tyrosine kinase inhibitors.

公开(公告)号：US20210024538A1

公开(公告)日：2021-01-28

申请号：US16968206

申请日：2019-01-29

申请人： MEDSHINE DISCOVERY INC.

发明人： Jian Xiong ,  Jingjing WANG ,  Boyu HU ,  Haizhong TAN ,  KEVIN X CHEN ,  jIAN li ,  Shuhui CHEN

IPC分类号： C07D495/04

摘要： A crystal form A of a 3,4-dihydrothieno[3,2-d]pyrimidine compound (1), a preparation method therefor and an application thereof in the preparation of an anti-human cytomegalovirus (HCMV) drug.

公开(公告)号：US10851112B2

公开(公告)日：2020-12-01

申请号：US16323074

申请日：2017-08-08

申请人： MEDSHINE DISCOVERY INC.

发明人： Jian Xiong ,  Jingjing Wang ,  Wentao Wu ,  Haizhong Tan ,  Xuanjia Peng ,  Yang Zhang ,  Kevin X. Chen ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D495/04 ,  A61P31/22 ,  A61K31/519

摘要： Disclosed are a class of fused cyclic compounds against the HCMV virus, and use thereof in the preparation of a drugs for treating diseases associated with the HCMV virus. In particular, disclosed is the compound shown in formula (II) and pharmaceutically acceptable salts thereof.

公开(公告)号：US10676474B2

公开(公告)日：2020-06-09

申请号：US16470111

申请日：2017-12-15

申请人： CSTONE PHARMACEUTICALS ,  MEDSHINE DISCOVERY INC.

发明人： Zhaobing Xu ,  Lihong Hu ,  Charles Z. Ding ,  Shuhui Chen

IPC分类号： A61K31/497 ,  C07D241/20 ,  C07D471/04 ,  A61P35/00 ,  C07D519/00

摘要： Disclosed is a series of compounds acting as CDK4/6 inhibitors. Specifically disclosed are compounds as represented by formula (I), pharmaceutically acceptable salts or isomers thereof, pharmaceutical compositions containing same, and the use thereof in the preparation of drugs for treating cancers.

公开(公告)号：US20200039995A1

公开(公告)日：2020-02-06

申请号：US16491769

申请日：2018-03-09

申请人： FUJIAN COSUNTER PHARMACEUTICAL CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Fei SUN ,  Jinhua DU ,  Yanbin HU ,  Lili ZHOU ,  Charles Z. DING ,  Shuhhui CHEN

IPC分类号： C07D491/052 ,  A61P31/20

摘要： 10-oxo-6,1-dihydrobenzo[e]pyrido[1,2-c][1,3]oxazine-9-carboxylic acid derivatives of formula (I) as hepatitis B surface antigen inhibitors or pharmaceutically acceptable salts thereof, and uses of a compound of formula (I) or pharmaceutically acceptable salts thereof and pharmaceutical compositions thereof in preparation of medicaments for treatment of viral hepatitis B.

公开(公告)号：US10508103B2

公开(公告)日：2019-12-17

申请号：US16096848

申请日：2017-04-27

申请人： MEDSHINE DISCOVERY INC.

发明人： Fei Sun ,  Charles Z. Ding ,  Zhe Cai ,  Wenyuan Qian ,  Guoping Hu ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D403/14 ,  A61P35/00 ,  A61P31/20 ,  A61K31/4184

摘要： The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in formulas (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180148452A1

公开(公告)日：2018-05-31

申请号：US15573990

申请日：2015-12-29

申请人： MEDSHINE DISCOVERY INC.

发明人： Charles Z. DING ,  Fei SUN ,  Lifang WU ,  Jinhua DU ,  Yasuhiro KATSU ,  Guoping HU ,  Jian LI

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61P35/00 ,  A61P37/08 ,  A61P11/06

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61P11/06 ,  A61P35/00 ,  A61P37/08 ,  C07D519/00

摘要： Disclosed are a novel pyrrolopyrimidine ring compound as a TLR7 agonist or a pharmaceutically acceptable salt thereof, used for preventing or treating allergic rhinitis and asthma. In particular, disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240327433A1

公开(公告)日：2024-10-03

申请号：US18275178

申请日：2022-01-27

申请人： Medshine Discovery Inc.

发明人： Yang Zhang ,  Wentao Wu ,  Zhixiang Li ,  Wenyuan Zuh ,  Ping Yang ,  Qiu Li ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D519/00 ,  A61K31/519 ,  A61K31/551

CPC分类号： C07D519/00 ,  A61K31/519 ,  A61K31/551

摘要： The present application relates to a pyrimidopyran compound, and specifically discloses a compound as represented by formula (III), and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240262837A1

公开(公告)日：2024-08-08

申请号：US18632254

申请日：2024-04-10

申请人： MEDSHINE DISCOVERY INC.

发明人： Peng LI ,  Xiaolin LI ,  Yaxun YANG ,  Zhi LUO ,  Haiying HE ,  Shuhui CHEN

IPC分类号： C07D487/04 ,  A61K31/53

CPC分类号： C07D487/04 ,  A61K31/53

摘要： Disclosed are a series of deuterated nucleoside compounds and a use thereof. Specifically disclosed are compounds represented by formula (VI-1), stereoisomers or pharmaceutically acceptable salts thereof.