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公开(公告)号：US07060699B2
公开(公告)日：2006-06-13
申请号：US10276160
申请日：2001-06-20
申请人： Dan Peters , Gunnar M Olsen , Elsebet Østergaard Nielsen , Philip K. Ahring , Simon Feldbæk Nielsen , Tino Dyhring Jørgensen
发明人： Dan Peters , Gunnar M Olsen , Elsebet Østergaard Nielsen , Philip K. Ahring , Simon Feldbæk Nielsen , Tino Dyhring Jørgensen
IPC分类号： C07D487/08 , C07D471/08 , A61K31/551 , A61K31/395 , A61P25/28
CPC分类号： C07D487/08
摘要： The present invention relates to novel aryl and heteroaryl diazabicycloalkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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122.发明授权Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效色烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US08153797B2
公开(公告)日：2012-04-10
申请号：US12160403
申请日：2007-02-13
IPC分类号： C07D221/02 , C07D225/00 , C07D401/00
CPC分类号： C07D451/06
摘要： This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型色烯-2-酮衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2011/12/06/US08071598B2/abs.jpg.150x150.jpg)
123.发明授权3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US08071598B2
公开(公告)日：2011-12-06
申请号：US12716111
申请日：2010-03-02
IPC分类号： A61K31/495
CPC分类号： C07D471/08
摘要： 3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions comprising the compounds. The 3,9-diazabicyclo[3.3.1]nonane derivatives have the formula wherein Ra and Rb are as described in the application. Also disclosed are stereoisomers and pharmaceutically acceptable salts of the compounds.
摘要翻译： 3,9-二氮杂双环[3.3.1]壬烷衍生物，可用作单胺神经递质再摄取抑制剂。 此外，在治疗方法中使用这些化合物和包含该化合物的药物组合物。 3,9-二氮杂双环[3.3.1]壬烷衍生物具有下式其中Ra和Rb如申请中所述。 还公开了化合物的立体异构体和药学上可接受的盐。
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124.发明申请PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER 审中-公开用于治疗CNS疾病的PIPERIDYLPROPIONAMIDE衍生物，包括呕吐和泛滥性疾病公开(公告)号：US20110218217A1
公开(公告)日：2011-09-08
申请号：US13061353
申请日：2009-08-25
IPC分类号： A61K31/445 , C07D211/34 , A61K31/4465 , A61P25/00 , A61P25/24 , A61P25/22 , A61P3/04 , A61P25/16 , A61P25/28 , A61P25/30 , A61P25/34 , A61P25/32 , A61P29/00 , A61P19/02 , A61P25/06 , A61P1/00
CPC分类号： C07D211/34
摘要： This invention relates to novel piperidine-4-propionamide derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型哌啶-4-丙酰胺衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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125.发明授权Carboxylic acid 4-phenylazo-phenyl ester derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效羧酸4-苯基偶氮苯酯衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07994156B2
公开(公告)日：2011-08-09
申请号：US12745530
申请日：2008-11-27
IPC分类号： C07D487/08 , C07D295/205 , C07D471/08 , C07D243/08 , A61K31/551 , A61K31/4353 , A61K31/4985 , A61P25/00
CPC分类号： C07D487/08 , C07D243/08 , C07D295/205 , C07D471/08
摘要： This invention relates to novel carboxylic acid 4-phenylazo-phenyl ester derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型羧酸4-苯基偶氮苯基酯衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![NOVEL 3,8-DIAZA-BICYCLO[3.2.1]OCTANE-AND 3,9-DIAZA-BICYCLO[3.3.1]-NONANE-3-CARBOXYLIC ACID ESTER DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS](/abs-image/US/2011/04/21/US20110092487A1/abs.jpg.150x150.jpg)
126.发明申请NOVEL 3,8-DIAZA-BICYCLO[3.2.1]OCTANE-AND 3,9-DIAZA-BICYCLO[3.3.1]-NONANE-3-CARBOXYLIC ACID ESTER DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开新的3,8-二氮杂双环[3.2.1]月桂和3,9-二氮杂双环[3.3.1] - 壬-3-烯羧酸酯衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20110092487A1
公开(公告)日：2011-04-21
申请号：US12920965
申请日：2009-02-27
IPC分类号： A61K31/55 , C07D471/08 , A61K31/4995 , A61P25/00 , A61P25/24 , A61P25/22 , A61P3/04 , A61P25/16 , A61P25/28 , A61P25/30
CPC分类号： C07D471/08 , C07D487/08
摘要： This invention relates to novel 3,8-diaza-bicyclo[3.2.1]octane-and 3,9-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid ester derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. Formula (I).
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新的3,8-二氮杂 - 双环[3.2.1]辛烷和3,9-二氮杂 - 双环[3.3.1]壬烷-3-羧酸酯衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。 式（I）。
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127.发明申请NOVEL PIPERIDINE-4-CARBOXYLIC ACID PHENYL-ALKYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开新型哌啶-4-羧酸 - 苯甲酰胺衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20110053985A1
公开(公告)日：2011-03-03
申请号：US12812898
申请日：2009-01-14
IPC分类号： A61K31/445 , C07D211/32 , A61P25/00 , A61P25/24 , A61P25/16 , A61P25/28 , A61P37/00 , A61P25/30 , A61P29/00 , A61P25/06 , A61P13/02
CPC分类号： C07D211/62
摘要： This invention relates to novel piperidine-4-carboxylic acid phenyl-alkyl-amide derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型哌啶-4-羧酸苯基 - 烷基 - 酰胺衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![NOVEL PHENYLETHYNYL DERIVATIVES OF 8-AZA-BICYCLO[3.2.1]OCTANE AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS](/abs-image/US/2011/01/20/US20110015235A1/abs.jpg.150x150.jpg)
128.发明申请NOVEL PHENYLETHYNYL DERIVATIVES OF 8-AZA-BICYCLO[3.2.1]OCTANE AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开8-AZA-BICYCLO [3.2.1] OCTAN的新型苯乙烯衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20110015235A1
公开(公告)日：2011-01-20
申请号：US12866044
申请日：2009-02-04
IPC分类号： A61K31/4439 , C07D401/12 , C07D209/52 , A61K31/403 , A61P25/24 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/30 , A61P25/34 , A61P25/36 , A61P25/32 , A61P29/00 , A61P19/02 , A61P15/10 , A61P13/00 , A61P15/12 , A61P21/00 , A61P25/22 , A61P3/04
CPC分类号： C07D451/06
摘要： This invention relates to novel phenylethynyl derivatives of 8-aza-bicyclo[3.2.1]octane useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的8-氮杂 - 双环[3.2.1]辛烷的新型苯乙炔衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Novel Azabicyclo[3.2.1]Oct-2-Ene Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors](/abs-image/US/2010/11/11/US20100286193A1/abs.jpg.150x150.jpg)
129.发明申请Novel Azabicyclo[3.2.1]Oct-2-Ene Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors 审中-公开新型氮杂双环[3.2.1] Oct-2-Ene衍生物及其作为单胺神经递质重吸收抑制剂的用途公开(公告)号：US20100286193A1
公开(公告)日：2010-11-11
申请号：US11990015
申请日：2006-08-30
IPC分类号： A61K31/46 , C07D451/04 , C07D451/02 , A61P25/00 , A61P25/24 , A61P15/10 , A61P25/16 , A61P25/28 , A61P29/00
CPC分类号： C07D451/02
摘要： This invention relates to novel azabicyclo[3.2.1]oct-2-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型氮杂双环[3.2.1]辛-2-烯衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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130.发明申请NOVEL PHENOXAZIN-3-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开新型苯氧基-3-酮衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20100286134A1
公开(公告)日：2010-11-11
申请号：US12677053
申请日：2008-09-08
IPC分类号： A61K31/538 , C07D451/12 , A61P25/00 , A61P25/24 , A61P25/28 , A61P15/00 , A61P29/00 , A61P25/30
CPC分类号： C07D413/12
摘要： This invention relates to novel phenoxazin-3-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新的吩恶嗪-3-酮衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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