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公开(公告)号：US4892778A
公开(公告)日：1990-01-09
申请号：US054714
申请日：1987-05-27
CPC分类号： A61M31/002 , A61K9/0004 , Y10S428/913 , Y10T428/24992 , Y10T428/31504 , Y10T428/31511 , Y10T428/31909 , Y10T428/31978
摘要： A dispenser is enclosed for delivering a beneficial agent to an enviroment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.
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公开(公告)号：US4853229A
公开(公告)日：1989-08-01
申请号：US112189
申请日：1987-10-26
申请人： Felix Theeuwes
发明人： Felix Theeuwes
CPC分类号： A61K9/0004 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K9/5078 , Y10S514/963
摘要： A delivery system is disclosed for delivering a beneficial agent to an environment of use. The delivery system comprises a plurality of tiny dosage forms comprising a beneficial agent. The delivery system also comprises means for maintaining (a) the physical and chemical integrity of the dosage form and for (b) inhibiting delivery of the beneficial agent during non-performance of the delivery system.
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公开(公告)号：US4851229A
公开(公告)日：1989-07-25
申请号：US150124
申请日：1988-01-29
CPC分类号： A61K9/0004 , A61M31/002
摘要： An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
摘要翻译： 公开了一种渗透递送系统，用于以受控和恒定的速率递送有用的试剂，该有用试剂通过有用试剂的脉冲输送调节到使用环境。
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公开(公告)号：US4837111A
公开(公告)日：1989-06-06
申请号：US173524
申请日：1988-03-21
IPC分类号： A61K9/00 , A61K9/22 , A61K9/36 , A61K31/505 , A61P25/02
CPC分类号： A61K9/0004 , A61K31/505
摘要： An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.
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135.发明授权
公开(公告)号：US4824675A
公开(公告)日：1989-04-25
申请号：US72506
申请日：1987-07-13
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
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公开(公告)号：US4800056A
公开(公告)日：1989-01-24
申请号：US829356
申请日：1986-02-14
CPC分类号： A61K9/0004 , A61M31/002
摘要： A method of forming a dispenser for delivering a beneficial agent to a biological environment. A beneficial agent and an expandable composition are placed in a capsule made of fluid dissolvable material. The capsule is closed and surrounded by a semipermeable wall which is permeable to fluid but not to the beneficial agent. Then a passageway is drilled in the capsule between the exterior and the interior which contains the beneficial agent.
摘要翻译： 一种形成用于将有益剂输送到生物环境的分配器的方法。 将有益剂和可发性组合物置于由可流体溶解的材料制成的胶囊中。 胶囊被封闭并被可渗透流体而不是有益剂的半透壁围绕。 然后在包含有益剂的外部和内部之间的胶囊中钻出通道。
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公开(公告)号：US4773907A
公开(公告)日：1988-09-27
申请号：US037489
申请日：1987-04-13
申请人： John Urquhart , Felix Theeuwes
发明人： John Urquhart , Felix Theeuwes
CPC分类号： A61J3/07 , A61J3/071 , A61K9/0004
摘要： A delivery system is disclosed comprising a wall surrounding a lumen containing a plurality of dosage delivery devices. The wall is formed of an environment sensitive material that releases the dosage forms into the environment. The dosage forms comprise a semipermeable wall surrounding a compartment containing drug. A passageway through the semipermeable wall releases drug from the dosage form to the environment.
摘要翻译： 公开了包括围绕包含多个剂量递送装置的内腔的壁的输送系统。 该壁由将剂型释放到环境中的环境敏感材料形成。 剂型包括围绕含有药物的隔室的半透壁。 通过半透壁的通道将药物从剂型释放到环境中。
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138.发明授权
公开(公告)号：US4740198A
公开(公告)日：1988-04-26
申请号：US702292
申请日：1985-02-15
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
摘要翻译： 公开了一种配制腔，其包括围绕包含用于递送有益剂的装置的内腔的壁。 腔室具有用于允许流体进入腔室的入口和用于使药剂制剂离开腔室的出口。 腔室适用于静脉输送系统，用于将药剂配制物递送给患者。
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139.发明授权Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use 失效输送系统包括用于在所选择的使用环境中屏蔽多个储存器的装置
公开(公告)号：US4721613A
公开(公告)日：1988-01-26
申请号：US651408
申请日：1984-09-17
申请人： John Urquhart , Felix Theeuwes
发明人： John Urquhart , Felix Theeuwes
CPC分类号： A61K9/2081
摘要： A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.
摘要翻译： 公开了用于将试剂递送到pH大于3.5的所选择的使用环境的递送系统。
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公开(公告)号：US4678467A
公开(公告)日：1987-07-07
申请号：US829351
申请日：1986-02-13
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译： 公开了一种用于将有益剂递送到使用环境的分配器。 分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。 墙壁上的通道将隔间与分配器的外部相连。
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