公开(公告)号：US20220267322A1

公开(公告)日：2022-08-25

申请号：US17625599

申请日：2020-07-10

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Jianfei WANG ,  Haizhong TAN ,  Jie LI ,  Yang ZHANG ,  Jian LI ,  Shuhui CHEN

IPC: C07D471/04 ,  A61P35/00

Abstract: Provided are a class of multi-targeted inhibitors of IRAK4 and BTK, and the use thereof in preparing a drug for treating IRAK4- and BTK-related diseases. The present invention specifically relates to the compounds represented by formula (II), isomers thereof or pharmaceutically acceptable salts thereof.

公开(公告)号：US20220267321A1

公开(公告)日：2022-08-25

申请号：US17622570

申请日：2020-06-24

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Yingchun LIU ,  Zhaobing XU ,  Lihong HU ,  Charles Z. Z. DING ,  Wen JIANG ,  Jian LI ,  Shuhui CHEN

IPC: C07D471/04 ,  A61P35/00

Abstract: The present invention discloses new azaindole pyrazole compounds as CDK9 inhibitors, in particular, compounds as represented by formula (I), pharmaceutically acceptable salts and isomers thereof, and the use of compounds represented by formula (I), pharmaceutically acceptable salts and isomers thereof, and the pharmaceutical composition containing them in the preparation of cancer drugs.

公开(公告)号：US20220267310A1

公开(公告)日：2022-08-25

申请号：US17622522

申请日：2020-06-24

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Kevin X Chen ,  Zhaoguo Chen ,  Li Zhang ,  Boyu Hu ,  Shuhui Chen

IPC: C07D413/14 ,  A61P35/00

Abstract: Disclosed in the present invention are a compound as represented by formula (I), and an isomer or pharmaceutically acceptable salt thereof, and disclosed is an application thereof in preparing drugs for treating DNA-PK inhibitor-related diseases.

公开(公告)号：US20220242851A1

公开(公告)日：2022-08-04

申请号：US17620464

申请日：2020-06-19

Applicant: SHENZHEN JINRUI FOUNDATION BIOTECH CO., LTD ,  MEDSHINE DISCOVERY INC.

Inventor： Kevin X. CHEN ,  Li ZHANG ,  Kai ZHOU ,  Yanxin YU ,  Boyu HU ,  Huiyu ZHANG

IPC: C07D403/12 ,  A61P35/00

Abstract: The present invention relates to a crystal form and a salt of a compound serving as a Pan-HER tyrosine kinase inhibitor and a preparation method therefor, and also use thereof in the preparation of a medicament for treating solid tumors.

公开(公告)号：US20220235029A1

公开(公告)日：2022-07-28

申请号：US17613613

申请日：2020-05-22

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Gang LI ,  Kun WANG ,  Lihong HU ,  Charles Z. DING

IPC: C07D401/12

Abstract: A crystal form and a salt form of a uracil compound acting as a c-MET/AXL inhibitor and a preparation method therefor, specifically relating to the crystal form and the salt form of the compound shown in formula (I), and also comprising an application of the crystal form and the salt form in the preparation of drugs for the treatment of tumours.

公开(公告)号：US20220227758A1

公开(公告)日：2022-07-21

申请号：US17597126

申请日：2020-06-24

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Jianfei WANG ,  Jie LI ,  Haizhong TAN ,  Yang ZHANG ,  Jian LI ,  Shuhui CHEN

IPC: C07D471/04 ,  A61P19/02 ,  A61P35/00

Abstract: A class of IRAK4 inhibitors are used in the preparation of drugs for the treatment of diseases related to IRAK4. A compound as represented by formula (II), an isomer thereof or a pharmaceutically acceptable salt thereof is an example of the IRAK4 inhibitors.

公开(公告)号：US20220220104A1

公开(公告)日：2022-07-14

申请号：US17600900

申请日：2020-04-03

Applicant: GUANGZHOU BAIYUNSHAN PHARMACEUTICAL HOLDINGS CO., LTD. BAIYUNSHAN PHARMACEUTICAL GENERAL FACTORY ,  MEDSHINE DISCOVERY INC.

Inventor： Jiansong WANG ,  Zhengxia CHEN ,  Zhibo LUO ,  Meibi DAI ,  Yang ZHANG ,  Shuhui CHEN ,  Yingxia BAO ,  Wei WANG ,  Zhoufan XIE

IPC: C07D471/04 ,  C07D519/00 ,  C07D491/04 ,  A61P35/00

Abstract: Disclosed is a series of pyrazolopyridine compounds, and application thereof in the preparation of RET kinase inhibitors for treatment. Specifically disclosed is the compound represented by formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220204508A1

公开(公告)日：2022-06-30

申请号：US17604336

申请日：2020-04-15

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Yaxian Cai ,  Xiaobing Yan ,  Ting Wang ,  Chengde Wu ,  Charles Z. Ding ,  Shuhui Chen

IPC: C07D471/18

Abstract: Disclosed are a class of macrocyclic derivatives, a preparation method therefor, a pharmaceutical composition containing the derivatives, and the use thereof as therapeutic agents, particularly as XIa factor inhibitors and in the preparation of a drug for treating and preventing thromboembolisms and other diseases. Particularly disclosed are compounds shown by formula (I), an isomer thereof and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220194959A1

公开(公告)日：2022-06-23

申请号：US17602736

申请日：2020-04-10

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Xile LIU ,  Lu ZHANG ,  Charles Z. DING ,  Shuhui CHEN ,  Lihong HU

IPC: C07D498/10

Abstract: Disclosed are a crystal form of an EGFR inhibitor and a preparation method thereof. Further disclosed is an application of the crystal form in preparing a drug for treating non-small cell lung cancer, especially an application in preparing a drug for treating non-small cell lung cancer with brain metastases.

公开(公告)号：US20220127243A1

公开(公告)日：2022-04-28

申请号：US17309611

申请日：2019-12-18

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Peng LI ,  Xiaolin LI ,  Zhi LUO ,  Haiying HE ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC: C07D401/04 ,  A61P27/02 ,  C07D401/06 ,  C07D401/12 ,  C07D213/73

Abstract: Provided is an aldehyde binder, specifically, disclosed is a compound as represented by formula (II) or a pharmaceutically acceptable salt.