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    Collaborative artificial intelligence method and system
    142.
    发明授权
    Collaborative artificial intelligence method and system 有权

    公开(公告)号：US11594222B2

    公开(公告)日：2023-02-28

    申请号：US17387785

    申请日：2021-07-28

    申请人： Tempus Labs, Inc.

    发明人： Eric Lefkofsky ,  Jonathan Ozeran

    IPC分类号： G10L15/22 ,  G16H10/60 ,  G16H50/20 ,  G16H70/60 ,  G16H50/50 ,  G16H40/20 ,  G06F16/632 ,  H04B1/3827 ,  G16H70/20 ,  G06F3/0481 ,  G06F3/16

    摘要： A method and system of audibly broadcasting responses to a user based on user queries about a specific patient molecular report, the method comprising receiving an audible query from the user to a microphone coupled to a collaboration device, identifying at least one intent associated with the audible query, identifying at least one data operation associated with the at least one intent, associating each of the at least one data operations with a first set of data presented on the molecular report, executing each of the at least one data operations on a second set of data to generate response data, generating an audible response file associated with the response data and providing the audible response file for broadcasting via a speaker coupled to the collaboration device.

    SYSTEMS AND METHODS FOR JOINT LOW-COVERAGE WHOLE GENOME SEQUENCING AND WHOLE EXOME SEQUENCING INFERENCE OF COPY NUMBER VARIATION FOR CLINICAL DIAGNOSTICS
    146.
    发明申请
    SYSTEMS AND METHODS FOR JOINT LOW-COVERAGE WHOLE GENOME SEQUENCING AND WHOLE EXOME SEQUENCING INFERENCE OF COPY NUMBER VARIATION FOR CLINICAL DIAGNOSTICS 有权

    公开(公告)号：US20220215900A1

    公开(公告)日：2022-07-07

    申请号：US17571412

    申请日：2022-01-07

    申请人： Tempus Labs, Inc.

    发明人： Francisco M. De La Vega

    IPC分类号： G16B20/10 ,  G16B20/20 ,  G16B30/10 ,  G16B40/20 ,  G16H50/20

    摘要： Methods, systems, and software are provided for determining copy number variation status of a subject. A first plurality of nucleic acid sequences generated by whole genome sequencing at an average depth of 0.5× to 5× is obtained from a first sample. A second plurality of nucleic acid sequences generated by panel-targeted sequencing is obtained from a second sample. A first mapped dataset is obtained by mapping the first plurality of sequences to positions within a reference genome for the species of the subject. A second mapped dataset is obtained by mapping the second plurality of sequences to positions within a reference construct for genomic regions targeted by the panel-targeted sequencing. A model is applied to all or a portion of the first mapped dataset and all or a portion of the second mapped dataset, or dimensionality reduction components thereof.

    Systems and Methods for Detecting Multi-Molecule Biomarkers
    147.
    发明申请
    Systems and Methods for Detecting Multi-Molecule Biomarkers 有权

    公开(公告)号：US20220213548A1

    公开(公告)日：2022-07-07

    申请号：US17566088

    申请日：2021-12-30

    申请人： Tempus Labs, Inc.

    发明人： Timothy Rand

    IPC分类号： C12Q1/6883 ,  C12Q1/6813

    摘要： The present disclosure provides methods, systems, compositions, and kits for the high-throughput detection of multi-molecule biomarkers in a biological sample. The disclosed methods, systems, compositions, and kits utilize antibody-oligonucleotide tags to detect two or more molecules that are in close proximity.

    ARTIFICIAL INTELLIGENCE DRIVEN THERAPY CURATION AND PRIORITIZATION
    148.
    发明申请
    ARTIFICIAL INTELLIGENCE DRIVEN THERAPY CURATION AND PRIORITIZATION 有权

    公开(公告)号：US20220208305A1

    公开(公告)日：2022-06-30

    申请号：US17546049

    申请日：2021-12-09

    申请人： Tempus Labs, Inc.

    发明人： Martin Bontrager ,  Ashleigh McBratney ,  Emily Kudalkar ,  Daniel Ben-Isvy ,  Robert Huether ,  Andrew Walker ,  Norah Jacob

    IPC分类号： G16B30/10 ,  G16B40/20 ,  G16B40/30 ,  G16H20/40 ,  G06N3/12

    摘要： A method for associating published media with a subject includes receiving a cancerous biological specimen, sequencing it to obtain subject genomic data, identifying first and second alteration nomenclature matches to the subject genomic data in data extracted from first and second published media, applying a hierarchical rule set to the media based on the alteration nomenclature matches and one or more evidence metrics, the hierarchical rule set resulting in reporting a first treatment in the first medium and excluding reporting of a second treatment in the second medium despite a match between the second medium and subject disease states, identifying a reporting template based on the subject genomic data and the disease state, generating a report using the identified template, the report reporting treatments according to the hierarchical rule set, comparing the report to one or more approval criteria, and publishing the report when the approval criteria are satisfied.