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公开(公告)号：US20210358571A1
公开(公告)日：2021-11-18
申请号：US17302867
申请日：2021-05-13
申请人： Tempus Labs, Inc.
发明人： Sumaiya Islam , Robert Huether
摘要： A method of categorizing fusions is provided by the present disclosure. The method includes receiving labeled fusion data including at least one of DNA data or RNA data including at least one detected fusion associated with a specimen, providing the labeled fusion data to a classifier trained to generate a pathogenicity metric corresponding to pathogenicity of each detected fusion, receiving at least one pathogenicity metric from the classifier, and generating a report including one or more detected fusions included in the at least one detected fusion based on the pathogenicity metrics.
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公开(公告)号：US20220208305A1
公开(公告)日：2022-06-30
申请号：US17546049
申请日：2021-12-09
申请人： Tempus Labs, Inc.
发明人： Martin Bontrager , Ashleigh McBratney , Emily Kudalkar , Daniel Ben-Isvy , Robert Huether , Andrew Walker , Norah Jacob
摘要： A method for associating published media with a subject includes receiving a cancerous biological specimen, sequencing it to obtain subject genomic data, identifying first and second alteration nomenclature matches to the subject genomic data in data extracted from first and second published media, applying a hierarchical rule set to the media based on the alteration nomenclature matches and one or more evidence metrics, the hierarchical rule set resulting in reporting a first treatment in the first medium and excluding reporting of a second treatment in the second medium despite a match between the second medium and subject disease states, identifying a reporting template based on the subject genomic data and the disease state, generating a report using the identified template, the report reporting treatments according to the hierarchical rule set, comparing the report to one or more approval criteria, and publishing the report when the approval criteria are satisfied.
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