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公开(公告)号：US11471275B2
公开(公告)日：2022-10-18
申请号：US16888649
申请日：2020-05-29
发明人： Salvador Marquez , Da-Yu Chang , Cindy Woo , Hao-Chung Yang , Lynn T. Dang , Javier A. Sanguinetti , Alexander H. Siemons , Yaron Keidar , Virginia Qi Lin , Brian S. Conklin , Donald E. Bobo, Jr.
摘要： Sensor-integrated prosthetic valves that can comprise a variety of features, including a plurality of valve leaflets, a frame assembly configured to support the plurality of valve leaflets and define a plurality of commissure supports terminating at an outflow end of the prosthetic valve, a sensor device associated with the frame assembly and configured to generate a sensor signal, for example, a sensor signal indicating deflection of one or more of the plurality of commissure supports, and a transmitter assembly configured to receive the sensor signal from the sensor device and wirelessly transmit a transmission signal that is based at least in part on the sensor signal.
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公开(公告)号：US20220313429A1
公开(公告)日：2022-10-06
申请号：US17806928
申请日：2022-06-14
发明人： Da-Yu Chang , Amy E. Munnelly , Van Huynh , Avina Gupta , Brian S. Conklin , Sooji Van Echten , Kurt Kelly Reed , Amanda Grace Sall
IPC分类号： A61F2/24
摘要： A prosthetic heart valve has a plurality of valve leaflets that control directional flow of blood through a heart and a stent structure having a plurality of commissure posts supporting the valve leaflets. The stent structure has a covering over the plurality of commissure posts and has a sewing ring at an inflow end of the stent structure. Each of the plurality of commissure posts has a tip and a suture loop is attached to the covering at a location adjacent to or on the tip of the commissure post. Each suture loop provides a passage for a suture to pass through between the covering and the suture loop.
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公开(公告)号：US11376125B2
公开(公告)日：2022-07-05
申请号：US16673487
申请日：2019-11-04
发明人： Brian S. Conklin , Michael C. Murad
IPC分类号： A61F2/24
摘要： A valve holder for delivering a prosthetic heart valve to an implant site is in various embodiments configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. The valve holder can be configured to deploy or actuate automatically when performing preparatory steps that are already familiar to practitioners, such as attaching a delivery handle to the valve holder, so that the valve holders will not require additional steps or training to use. Therefore, operation of the valve holders is kept simple, and occurrences of mistakes caused by user error can be minimized or reduced. Valve holders according to different embodiments can be designed to accommodate implantation of prosthetic heart valves from either the inflow end or the outflow end of the native valve annulus.
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公开(公告)号：US20220110743A1
公开(公告)日：2022-04-14
申请号：US17645690
申请日：2021-12-22
发明人： Brian S. Conklin
IPC分类号： A61F2/24
摘要： A prosthetic heart valve can include a valve frame having a wireform portion and a stent portion. The wireform and stent portions can be undetachably coupled together via a plurality of upright struts so as to form a one-piece prosthetic heart valve frame. Alternatively, a self-expanding wireform portion and a balloon-expandable stent portion can be coupled together via one or more leaflets and a subassembly having a flexible leaflet support stent and a sealing ring. The wireform portion can include cusps and commissures configured to support a plurality of leaflets. The prosthetic valve can be radially collapsible for minimally invasive and/or transcatheter delivery techniques. Disclosed embodiments can also provide flexion of the wireform portion (e.g., of the commissures) in response to physiologic pulsatile loading when the valve is implanted in a patient's native valve annulus. Methods of making and using prosthetic heart valves are also disclosed.
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公开(公告)号：US11207178B2
公开(公告)日：2021-12-28
申请号：US16989826
申请日：2020-08-10
发明人： Brian S. Conklin
IPC分类号： A61F2/24
摘要： A prosthetic heart valve can include a valve frame having a wireform portion and a stent portion. The wireform and stent portions can be undetachably coupled together via a plurality of upright struts so as to form a one-piece prosthetic heart valve frame. Alternatively, a self-expanding wireform portion and a balloon-expandable stent portion can be coupled together via one or more leaflets and a subassembly having a flexible leaflet support stent and a sealing ring. The wireform portion can include cusps and commissures configured to support a plurality of leaflets. The prosthetic valve can be radially collapsible for minimally invasive and/or transcatheter delivery techniques. Disclosed embodiments can also provide flexion of the wireform portion (e.g., of the commissures) in response to physiologic pulsatile loading when the valve is implanted in a patient's native valve annulus. Methods of making and using prosthetic heart valves are also disclosed.
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公开(公告)号：US20210369277A1
公开(公告)日：2021-12-02
申请号：US17404931
申请日：2021-08-17
IPC分类号： A61B17/10 , A61B17/068 , A61B17/064 , A61B17/122 , A61B17/128
摘要： Devices and methods for deploying self-cinching surgical clips. A device can access at least two layers of tissue or material from only one side of the tissue or material and puncture through the two layers of tissue or material. The various configurations of clips disclosed herein can be made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip can be disposed within the housing of the delivery device and held in a constrained state until deployment wherein the clip assumes its relaxed state, where the ends of the clip can be brought into close approximation, thereby securing the layers of tissue or material together.
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公开(公告)号：US11090053B2
公开(公告)日：2021-08-17
申请号：US16356604
申请日：2019-03-18
IPC分类号： A61B17/10 , A61B17/068 , A61B17/064 , A61B17/122 , A61B17/128
摘要： Devices and methods for deploying self-cinching surgical clips. A device can access at least two layers of tissue or material from only one side of the tissue or material and puncture through the two layers of tissue or material. The various configurations of clips disclosed herein can be made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip can be disposed within the housing of the delivery device and held in a constrained state until deployment wherein the clip assumes its relaxed state, where the ends of the clip can be brought into close approximation, thereby securing the layers of tissue or material together.
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公开(公告)号：US20210145581A1
公开(公告)日：2021-05-20
申请号：US17159668
申请日：2021-01-27
发明人： Brian S. Conklin , Louis A. Campbell , Salvador Marquez , James R. Yamada , Rodolfo Rodriguez , Da-Yu Chang , Steven M. Ford
IPC分类号： A61F2/24
摘要： A minimally-invasive annuloplasty ring for implant at a mitral annulus. The annuloplasty ring has an inner core member with a C-shaped plan view that generally defines an oval with a major axis and a minor axis, and is symmetric about the minor axis. A posterior portion of the core member bisected by the minor axis has a thicker radial dimension than a pair of free end regions terminating on an anterior side of the core member. The radial thickness smoothly transitions between the posterior portion and the end regions. The inner core member may be covered with a fabric, and is a superelastic metal so that it can be straightened out and delivered through an access tube. The curvatures and thicknesses around the core member are selected so that the strain experienced when straightened does not exceed 7-8%.
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