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公开(公告)号：US07659403B2
公开(公告)日：2010-02-09
申请号：US11371603
申请日：2006-03-09
Applicant: YongQi Mu , Yu-Hua Ji , Mathai Mammen , Viengkham Malathong
Inventor： YongQi Mu , Yu-Hua Ji , Mathai Mammen , Viengkham Malathong
IPC: C07D211/94 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/444
CPC classification number: C07D211/46 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US07642355B2
公开(公告)日：2010-01-05
申请号：US11372294
申请日：2006-03-09
Applicant: YongQi Mu , Yu-Hua Ji , Mathai Mammen , Eric L. Stangeland
Inventor： YongQi Mu , Yu-Hua Ji , Mathai Mammen , Eric L. Stangeland
IPC: C07D211/40 , A61K31/445
CPC classification number: C07D211/46 , C07D405/12
Abstract: The invention provides compounds of formula I: wherein a, b, c, p, W, A, X1, R1, R2, R3, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
Abstract translation: 本发明提供式I化合物：其中a，b，c，p，W，A，X 1，R 1，R 2，R 3，R 6，R 7和R 8如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07632847B2
公开(公告)日：2009-12-15
申请号：US11371500
申请日：2006-03-09
Applicant: YongQi Mu , Yu-Hua Ji , Mathai Mammen , Viengkham Malathong
Inventor： YongQi Mu , Yu-Hua Ji , Mathai Mammen , Viengkham Malathong
IPC: A61K31/445 , C07D211/44 , C07D211/46
CPC classification number: C07D401/12 , C07D211/46 , C07D211/62 , C07D401/14 , C07D405/12 , C07D409/12
Abstract: The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
Abstract translation: 本发明提供式I化合物：其中a，b，c，m，n，q，r，w，Z1，Ar1，Z2，Y，R1，R2和R3如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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164.发明申请COMPOUNDS HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY 失效具有BETA2 ADRENERGIC受体激动剂和MUSCARINIC受体拮抗剂活性的化合物公开(公告)号：US20090239904A1
公开(公告)日：2009-09-24
申请号：US12479017
申请日：2009-06-05
Applicant: Mathai Mammen , Trevor Mischki , Adam Hughes , YuHua Ji
Inventor： Mathai Mammen , Trevor Mischki , Adam Hughes , YuHua Ji
IPC: A61K31/4709 , A61P11/08 , A61K31/445
CPC classification number: C07D401/12 , C07D401/14 , C07D409/14 , C07D417/14
Abstract: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8a, R8b, W, a, b, c and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity. Accordingly, such compounds are expected to be useful as therapeutic agents for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明提供了式I的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8a，R 8b，W，a，b，c和m如本说明书中所定义，或其药学上可接受的盐或溶剂合物 或其立体异构体。 本发明的化合物具有β2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性。 因此，预期这些化合物可用作治疗肺部疾病如慢性阻塞性肺疾病和哮喘的治疗剂。
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公开(公告)号：US07569588B2
公开(公告)日：2009-08-04
申请号：US11077224
申请日：2005-03-10
Applicant: Mathai Mammen , Yu-Hua Ji , YongQi Mu , Viengkham Malathong
Inventor： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Viengkham Malathong
IPC: A61K31/445 , C07D211/40 , C07D211/44
CPC classification number: C07D211/46 , C07D211/60 , C07D211/62 , C07D401/12 , C07D405/12
Abstract: This invention provides compounds of formula I: wherein a, b, c, m, p, r, R1, R2, R3, R4, R5, R6, W and X1 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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Patent Agency Ranking
公开(公告)号：US07550595B2
公开(公告)日：2009-06-23
申请号：US11880002
申请日：2007-07-19
Applicant: Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
Inventor： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC: C07D221/02 , C07D405/00 , C07D211/00
CPC classification number: C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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167.发明授权Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity 有权具有β2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性的化合物公开(公告)号：US07528253B2
公开(公告)日：2009-05-05
申请号：US11204066
申请日：2005-08-15
Applicant: Mathai Mammen , Trevor Mischki
Inventor： Mathai Mammen , Trevor Mischki
IPC: C07D215/38
CPC classification number: C07D213/40 , C07C271/28 , C07D215/26 , C07D277/28 , C07D333/20 , C07D409/12
Abstract: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8a, R8b, W, a and b are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor antagonist and muscarinic receptor antagonist activity. Accordingly, such compounds are expected to be useful as therapeutic agents for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明提供式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8a，R8b，W，a和b如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的化合物具有β2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性。 因此，预期这些化合物可用作治疗肺部疾病如慢性阻塞性肺疾病和哮喘的治疗剂。
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公开(公告)号：US07524962B2
公开(公告)日：2009-04-28
申请号：US11077349
申请日：2005-03-10
Applicant: Mathai Mammen , Yu-Hua Ji , YongQi Mu
Inventor： Mathai Mammen , Yu-Hua Ji , YongQi Mu
IPC: A61K31/444 , A61K31/45 , C07D211/44
CPC classification number: C07D211/62
Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，r，R1，R2，R3，R4，R5，R6，R7和W如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20090088453A1
公开(公告)日：2009-04-02
申请号：US12328033
申请日：2008-12-04
Applicant: Mathai Mammen , Yu-Hua Ji , YongQi Mu
Inventor： Mathai Mammen , Yu-Hua Ji , YongQi Mu
IPC: A61K31/4545 , C07D401/12 , A61P9/00 , A61P11/06
CPC classification number: C07D211/62 , C07D409/14
Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, Ar1, R1, R2, R3, R4, R6, R7, R8, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，Ar1，R1，R2，R3，R4，R6，R7，R8和W如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20090082397A1
公开(公告)日：2009-03-26
申请号：US12272070
申请日：2008-11-17
Applicant: Mathai Mammen , Yu-Hua Ji , YongQi Mu
Inventor： Mathai Mammen , Yu-Hua Ji , YongQi Mu
IPC: A61K31/4545 , C07D401/12
CPC classification number: C07D211/62
Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，r，R1，R2，R3，R4，R5，R6，R7和W如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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