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公开(公告)号：US20240327433A1
公开(公告)日：2024-10-03
申请号：US18275178
申请日：2022-01-27
Applicant: Medshine Discovery Inc.
Inventor： Yang Zhang , Wentao Wu , Zhixiang Li , Wenyuan Zuh , Ping Yang , Qiu Li , Jian Li , Shuhui Chen
IPC: C07D519/00 , A61K31/519 , A61K31/551
CPC classification number: C07D519/00 , A61K31/519 , A61K31/551
Abstract: The present application relates to a pyrimidopyran compound, and specifically discloses a compound as represented by formula (III), and a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240262837A1
公开(公告)日：2024-08-08
申请号：US18632254
申请日：2024-04-10
Applicant: MEDSHINE DISCOVERY INC.
Inventor： Peng LI , Xiaolin LI , Yaxun YANG , Zhi LUO , Haiying HE , Shuhui CHEN
IPC: C07D487/04 , A61K31/53
CPC classification number: C07D487/04 , A61K31/53
Abstract: Disclosed are a series of deuterated nucleoside compounds and a use thereof. Specifically disclosed are compounds represented by formula (VI-1), stereoisomers or pharmaceutically acceptable salts thereof.
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公开(公告)号：US20240239763A1
公开(公告)日：2024-07-18
申请号：US18556896
申请日：2022-04-21
Inventor： Yang ZHANG , Wentao WU , Zhixiang LI , Wenyuan ZHU
IPC: C07D333/72 , A61K31/381
CPC classification number: C07D333/72 , A61K31/381
Abstract: Provided are a crystal form of a compound represented by formula (I) and a preparation method therefor.
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公开(公告)号：US20240217953A1
公开(公告)日：2024-07-04
申请号：US18286326
申请日：2022-04-15
Inventor： Charles Z DING , Xiaobing YAN , Fei SUN , Wen JIANG , Jian LI , Shuhui CHEN
IPC: C07D403/06 , A61K31/404 , A61K31/439 , A61K31/4439 , C07D401/14 , C07D471/08 , C07D491/08
CPC classification number: C07D403/06 , A61K31/404 , A61K31/439 , A61K31/4439 , C07D401/14 , C07D471/08 , C07D491/08
Abstract: A bicyclic substituted aromatic carboxylic acid compound, in particular a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof. In formula (I), R2 and R3 and atoms connected thereto together form a 3-6 membered heterocyclic group, or R2 and R4 and atoms connected thereto together form a 3-6 membered heterocyclic group. The compound has obvious inhibitory activity on activation of a human serum alternative pathway and significant binding activity to human complement Factor B protein, and also has relatively good in-vivo pharmacodynamic and pharmacokinetic properties.
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公开(公告)号：US20240208945A1
公开(公告)日：2024-06-27
申请号：US18550468
申请日：2022-03-24
Applicant: MEDSHINE DISCOVERY INC.
Inventor： Lingyun WU , Tianzi DAI , Lele ZHAO , Jianjun SUN , Yi QIAN , Jian LI , Shuhui CHEN
IPC: C07D403/12 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/551 , A61P35/00 , C07D401/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/107
CPC classification number: C07D403/12 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/551 , A61P35/00 , C07D401/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/107
Abstract: Disclosed are 6-carbamate substituted heteroaryl ring derivatives and a preparation method therefor. The present application particularly relates to a compound as shown in formula (II) and a pharmaceutically acceptable salt thereof.
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Patent Agency Ranking
公开(公告)号：US20240190851A1
公开(公告)日：2024-06-13
申请号：US18549186
申请日：2022-03-16
Applicant: MEDSHINE DISCOVERY INC.
Inventor： Maoyi LEI , Junmiao LI , Shuhui CHEN
IPC: C07D405/14 , A61K31/454 , A61K31/496 , A61K31/501 , A61P35/00 , C07D493/04
CPC classification number: C07D405/14 , A61K31/454 , A61K31/496 , A61K31/501 , A61P35/00 , C07D493/04
Abstract: Disclosed are a series of furan fused ring-substituted glutarimide compounds and an application thereof in preparation of a drug for treating related diseases. In particular, disclosed is a compound represented by formula (II) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240174692A1
公开(公告)日：2024-05-30
申请号：US18276334
申请日：2022-02-09
Applicant: Medshine Discovery Inc.
Inventor： Yang Zhang , Wentao Wu , Kaijun Geng , Yangyang Xu , Zhixiang Li , Shuhui Chen
IPC: C07D519/00 , A61P35/00 , C07D487/04
CPC classification number: C07D519/00 , A61P35/00 , C07D487/04
Abstract: Provided are pyrimidine aromatic ring compounds. Specifically provided is a compound as represented by formula (II) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240132491A1
公开(公告)日：2024-04-25
申请号：US18275457
申请日：2022-02-08
Applicant: MEDSHINE DISCOVERY INC.
Inventor： Jianyu LU , Charles Z. DING , Huijun HE , Lihong HU , Yuanyuan HUANG , Jian LI , Shuhui CHEN
IPC: C07D471/04 , A61P35/00 , C07D519/00
CPC classification number: C07D471/04 , A61P35/00 , C07D519/00
Abstract: An indoline compound. Specifically disclosed is an application of a compound represented by formula (I) and pharmaceutically acceptable salts thereof in the preparation of drugs for treating related diseases.
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公开(公告)号：US20240132482A1
公开(公告)日：2024-04-25
申请号：US18274674
申请日：2022-01-29
Inventor： Zhengwei LI , Wenyuan QIAN , Shuhui CHEN
IPC: C07D405/14 , C07D401/14
CPC classification number: C07D405/14 , C07D401/14
Abstract: The present invention relates to a benzo seven-membered ring bifunctional compound and an application thereof, and in particular to a compound represented by formula (IV) and a pharmaceutically acceptable salt thereof. The compound can be used for preparing a drug for treating diseases related to an estrogen receptor protein degradation targeting chimera.
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公开(公告)号：US20240025921A1
公开(公告)日：2024-01-25
申请号：US18271162
申请日：2022-01-07
Applicant: PHAENO THERAPEUTICS CO., LTD. , MEDSHINE DISCOVERY INC.
Inventor： Kevin X CHEN , Jian XIONG , Jingjing WANG , Guoping HU , Jinxin LIU , Yu HAN , Jian LI , Shuhui CHEN
IPC: C07D519/00 , A61P31/16
CPC classification number: C07D519/00 , A61P31/16
Abstract: Provided are a class of pyridone multiple-membered ring derivatives and the use thereof. Specifically provided are a compound as represented by formula (VI) and a pharmaceutically acceptable salt thereof.
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