公开(公告)号：US20240166610A1

公开(公告)日：2024-05-23

申请号：US18263702

申请日：2022-01-29

申请人： MEDSHINE DISCOVERY INC.

发明人： Lingyun WU ,  Lele ZHAO ,  Jianjun SUN ,  Chuang QIAO ,  Shuhui CHEN

IPC分类号： C07D237/20 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D453/02 ,  C07D491/107 ,  C07D519/00

CPC分类号： C07D237/20 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D453/02 ,  C07D491/107 ,  C07D519/00

摘要： Substituted pyridazine phenol derivatives and a preparation method therefor, specifically relating to a compound as shown in formula (VI) and a pharmaceutically acceptable salt thereof, which can be used as an NLRP3 inhibitor.

公开(公告)号：US20240199571A1

公开(公告)日：2024-06-20

申请号：US18549188

申请日：2022-03-04

申请人： MEDSHINE DISCOVERY INC.

发明人： Lingyun WU ,  Zhen ZHAN ,  Lele ZHAO ,  Jianjun SUN ,  Yi QIAN ,  Shuhui CHEN

IPC分类号： C07D333/22 ,  A61K31/381 ,  A61K31/407 ,  A61K31/438 ,  A61K31/439 ,  A61K31/495 ,  A61K31/551 ,  C07D403/04 ,  C07D413/04

CPC分类号： C07D333/22 ,  A61K31/381 ,  A61K31/407 ,  A61K31/438 ,  A61K31/439 ,  A61K31/495 ,  A61K31/551 ,  C07D403/04 ,  C07D413/04

摘要： The present invention relates to a thiophene compound and an application thereof. The present invention specifically relates to a compound represented by formula (II) and a pharmaceutically acceptable salt thereof, wherein L1 is —C(═O)— or —C(═O)—NH—; R1 is R1a or aa; ring A is bb or cc; R1a is C1-3 alkyl substituted with 1, 2 or 3 Ra; and R3 is independently H, halogen or C1-3 alkoxy. The compound represented by formula (II) and the pharmaceutically acceptable salt thereof can better inhibit the activity of LSD1, further shows significant inhibitory activity against NCI-H1417 cell proliferation, and has good pharmacokinetic properties (including good oral bioavailability, oral exposure, half-life, and clearance rate, etc.).

公开(公告)号：US20240208945A1

公开(公告)日：2024-06-27

申请号：US18550468

申请日：2022-03-24

申请人： MEDSHINE DISCOVERY INC.

发明人： Lingyun WU ,  Tianzi DAI ,  Lele ZHAO ,  Jianjun SUN ,  Yi QIAN ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D403/12 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61P35/00 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107

CPC分类号： C07D403/12 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61P35/00 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107

摘要： Disclosed are 6-carbamate substituted heteroaryl ring derivatives and a preparation method therefor. The present application particularly relates to a compound as shown in formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220064126A1

公开(公告)日：2022-03-03

申请号：US17460662

申请日：2021-08-30

申请人： MEDSHINE DISCOVERY INC.

发明人： Lingyun WU ,  Lele ZHAO ,  Jianjun SUN ,  Zhen ZHAN ,  Shuhui CHEN

IPC分类号： C07D231/12 ,  C07D401/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D403/06 ,  C07D471/10 ,  C07D487/04

摘要： Disclosed are a class of pyrazole compounds and applications thereof in the preparation of a medicament for treating related diseases. Specifically, related are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20200345700A1

公开(公告)日：2020-11-05

申请号：US16479602

申请日：2018-01-24

申请人： MEDSHINE DISCOVERY INC.

发明人： Lingyun WU ,  Li ZHANG ,  Lele ZHAO ,  Jianjun SUN ,  Zhaoguo CHEN ,  Jian Ll ,  Shuhui CHEN

IPC分类号： A61K31/4245 ,  A61K33/243 ,  A61P35/00 ,  A61K31/277 ,  C07C255/46 ,  C07D257/04 ,  A61K31/41 ,  A61K31/135 ,  C07C211/40 ,  C07D207/335 ,  A61K31/40 ,  C07D207/09 ,  C07D233/64 ,  A61K31/417 ,  A61K31/4196 ,  C07D249/08 ,  C07D213/38 ,  A61K31/44 ,  A61K31/426 ,  C07D277/28 ,  C07D487/04 ,  A61K31/4188 ,  C07D271/06 ,  A61K31/165 ,  C07C233/58 ,  C07D413/04 ,  A61K31/4439 ,  A61K31/437 ,  C07D471/04 ,  C07D263/56 ,  A61K31/423 ,  A61K31/4375 ,  C07D217/26 ,  A61K31/472 ,  A61K31/451 ,  C07D211/18 ,  C07D211/34 ,  C07D209/44 ,  A61K31/4035 ,  A61K31/55 ,  C07D223/16 ,  C07D261/20 ,  A61K31/519 ,  C07D413/10 ,  C07D417/04 ,  A61K31/428 ,  A61K31/4192 ,  C07D249/06 ,  A61K31/4545 ,  C07D413/14 ,  A61K31/415 ,  C07D231/12 ,  C07D413/06 ,  A61K31/422

摘要： A cyclopropylamine compound as a lysine-specific demethylase 1 (LSD1) inhibitor. Particularly, the present invention relates to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof. The present invention also provides an application of the same in preparing a drug for treating an LSD1-related disease.