公开(公告)号：US20030185819A1

公开(公告)日：2003-10-02

申请号：US10428662

申请日：2003-05-02

申请人： Biogen, Inc., a Massachusetts corporation

发明人： Roy R. Lobb ,  Frank J. Carr ,  Philip R. Tempest

IPC分类号： A61K039/395 ,  C07H021/04 ,  C07K016/44 ,  C12P021/02 ,  C12N005/06

CPC分类号： C07K16/2842 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/92 ,  C07K2319/00

摘要： The present invention disclosed recombinant anti-VLA-4 antibody molecules, including humanized recombinant anti-VLA-4 antibody molecules. These antibodies are useful in the treatment of specific and non-specific inflammation, including asthma and inflammatory bowel disease. In addition, the humanized recombinant anti-VLA-4 antibodies disclosed can be useful in methods of diagnosing and localizing sites of inflammation.

公开(公告)号：US20020009449A1

公开(公告)日：2002-01-24

申请号：US09730465

申请日：2000-12-05

申请人： Biogen, Inc., a Massachusetts corporation

发明人： Barbara P. Wallner ,  Kevin D. Cooper

IPC分类号： A61K039/395

CPC分类号： G01N33/57426 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/70507 ,  C07K14/70528 ,  C07K16/2806 ,  C07K16/2824 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30 ,  G01N2333/70503 ,  G01N2333/70507 ,  G01N2500/00 ,  G01N2800/205 ,  Y10S514/863 ,  Y10S514/885

摘要： Methods of using inhibitors of the CD2/LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in mammals, including humans. Such conditions include psoriasis, UV damage, e.g., photoaging, atopic dermatitis, cutaneous T cell lymphoma such as mycosis fungoides, allergic and irritant contact dermatitis, lichen planus, alopecia areata, pyoderma gangrenosum, vitiligo, ocular cicatricial pemphigoid, and urticaria.

摘要翻译： 使用CD2 / LFA-3相互作用抑制剂治疗特征在于包括人在内的哺乳动物的真皮和表皮中的T细胞激活和异常抗原呈递的皮肤病症的方法。 这些病症包括牛皮癣，紫外线损伤，例如光老化，特应性皮炎，皮肤T细胞淋巴瘤，如蕈样真菌病，过敏性和刺激性接触性皮炎，扁平苔藓，斑秃，坏疽性坏死性侏儒症，白癜风，眼瘢痕性类天疱疮和荨麻疹。