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公开(公告)号:US20190094226A1
公开(公告)日:2019-03-28
申请号:US16199822
申请日:2018-11-26
IPC分类号: G01N33/573 , B01L3/00 , C12Q1/6804 , C12Q1/25 , C12Q1/6818 , G01N33/58 , G01N33/542 , C40B40/04 , C40B50/08 , B01F13/00 , B01F5/06 , B01J19/00 , G01N33/50 , B01F3/08 , C40B60/10 , C12Q1/6827 , B01L7/00 , G01N21/64
CPC分类号: G01N33/573 , B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C12Q1/25 , C12Q1/6804 , C12Q1/6818 , C12Q1/6827 , C40B40/04 , C40B50/08 , C40B60/10 , G01N21/6428 , G01N21/6445 , G01N33/5008 , G01N33/542 , G01N33/582 , G01N2500/00
摘要: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.
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公开(公告)号:US20180353913A1
公开(公告)日:2018-12-13
申请号:US16105042
申请日:2018-08-20
CPC分类号: B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01F2215/0037 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C40B40/04 , C40B50/08 , G01N15/1459 , G01N33/5008 , G01N2015/1006 , G01N2500/00 , Y02A90/26
摘要: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
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公开(公告)号:US20180320146A1
公开(公告)日:2018-11-08
申请号:US16030259
申请日:2018-07-09
发明人: Antonius G.P. Oomens
IPC分类号: C12N7/00 , C07K14/005 , C12Q1/06
CPC分类号: C12N7/00 , A61K2039/5254 , A61K2039/5258 , C07K14/005 , C12N2760/18511 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2760/18562 , C12Q1/06 , G01N2333/115 , G01N2500/00
摘要: Highly antigenic yet safe vaccines against diseases caused by Paramyxoviridae viruses such as respiratory syncytial virus (RSV) are provided. The vaccines comprise attenuated Paramyxoviridae viruses with high antigenicity but which display impaired cell-to-cell transmission as a result of genetic manipulation of the gene encoding the matrix (M) protein. In the viruses, the M protein is absent or mutated to a less active form. Screening or assay systems and methods for evaluating the infectivity of mutant M proteins anf for identifying suitable M candidates for live-attenuated vaccine virus and VLP production, are also provided.
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公开(公告)号:US20180291435A1
公开(公告)日:2018-10-11
申请号:US16012280
申请日:2018-06-19
申请人: The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Servic
发明人: Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号: C12Q1/6827 , G01N33/574 , C12Q1/26 , C12Q1/6886 , C12Q1/6869 , C12N5/0783 , C12N15/873 , C12N5/074 , C12Q1/6806 , G01N33/53 , C12N9/02 , C12N5/00 , G01N33/50
CPC分类号: C12Q1/6827 , C12N5/0018 , C12N5/0607 , C12N5/0637 , C12N5/0696 , C12N9/0071 , C12N15/873 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/71 , C12N2501/999 , C12N2506/1307 , C12N2506/1353 , C12N2510/00 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6886 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154 , G01N33/5011 , G01N33/5308 , G01N33/57426 , G01N33/57484 , G01N33/57496 , G01N2500/00
摘要: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号:US20180267051A1
公开(公告)日:2018-09-20
申请号:US15921371
申请日:2018-03-14
申请人: Omeros Corporation
发明人: Brian F. O'Dowd , Susan R. George
CPC分类号: G01N33/68 , C07K14/705 , C07K14/70571 , C07K14/71 , C07K14/723 , C07K2319/09 , C07K2319/60 , G01N33/5008 , G01N33/5035 , G01N33/5044 , G01N33/5058 , G01N33/6803 , G01N33/6863 , G01N33/92 , G01N2333/71 , G01N2333/72 , G01N2333/726 , G01N2458/00 , G01N2500/00
摘要: A method for screening compounds for their ability to interact with transmembrane proteins is provided. Also provided is a method for determining whether proteins such as transmembrane proteins are able to oligomerise.
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公开(公告)号:US20180265927A1
公开(公告)日:2018-09-20
申请号:US15914800
申请日:2018-03-07
IPC分类号: C12Q1/6883
CPC分类号: C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/47 , C12Q2600/156 , C12Q2600/158 , G01N33/6896 , G01N2500/00 , G01N2800/28
摘要: The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.
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7.
公开(公告)号:US10078085B2
公开(公告)日:2018-09-18
申请号:US14422912
申请日:2012-08-22
申请人: Hyung-Kwon Lim , Sung Geun Kim , Young Seoub Park , Hyo Jung Nam , Dong-Sik Kim , Jae Chan Park , Yeup Yoon
发明人: Hyung-Kwon Lim , Sung Geun Kim , Young Seoub Park , Hyo Jung Nam , Dong-Sik Kim , Jae Chan Park , Yeup Yoon
CPC分类号: G01N33/6857 , C07K16/00 , C07K16/18 , C07K16/32 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/94 , C07K2319/00 , C07K2319/10 , C40B40/10 , G01N2500/00
摘要: There are provided a method named Tat-associated protein engineering (TAPE), of screening a target protein having higher solubility and excellent thermostability, in particular, an immunoglobulin variable domain (VH or VL) derived from human germ cells, by preparing a gene construct where the target protein and an antibiotic-resistant protein are linked to a Tat signal sequence, and then expressing this within E. coli, and human or engineered VH and VL domain antibodies and human or engineered VH and VL domain antibody scaffolds having solubility and excellent thermostability, which are screened by the TAPE method. There are also provided a library including random CDR sequences in the human or engineered VH or VL domain antibody scaffold screened by the TAPE method, and a preparing method thereof. There are also provided a VH or VL domain antibody having binding ability to the target protein screened by using the library, and a pharmaceutical composition including the domain antibody.
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公开(公告)号:US10077244B2
公开(公告)日:2018-09-18
申请号:US14553445
申请日:2014-11-25
申请人: Promega Corporation
发明人: James J. Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John W. Shultz , James Unch , Michael P. Valley , Keith V. Wood , Wenhui Zhou
IPC分类号: C07D417/04 , C07D417/14 , C07D277/66 , C07D311/16 , C07D493/10 , C12Q1/66 , C07D277/68 , C09B11/24 , C09B19/00 , C09B57/00 , C09B57/02 , C07F9/6558
CPC分类号: C07D277/66 , C07D277/68 , C07D311/16 , C07D417/04 , C07D417/14 , C07D493/10 , C07F9/65583 , C09B11/24 , C09B19/00 , C09B57/00 , C09B57/02 , C12Q1/66 , G01N2500/00
摘要: A method to detect the presence of amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.
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公开(公告)号:US20180256669A1
公开(公告)日:2018-09-13
申请号:US15864856
申请日:2018-01-08
申请人: YAQRIT LIMITED
发明人: Rajiv JALAN , Naina SHAH
CPC分类号: A61K38/10 , A61K38/04 , G01N33/6893 , G01N2333/705 , G01N2500/00 , G01N2800/085 , G01N2800/28 , G01N2800/347 , G01N2800/52
摘要: The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and/or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction.
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10.
公开(公告)号:US20180256617A1
公开(公告)日:2018-09-13
申请号:US15784869
申请日:2017-10-16
IPC分类号: A61K31/704 , A61K31/733 , A61K31/198 , A61K45/06 , A61P35/00 , A61P25/28 , A61P3/04 , A61P3/10
CPC分类号: A61K31/704 , A61K31/198 , A61K31/733 , A61K45/06 , A61K2300/00 , A61P3/04 , A61P3/10 , A61P25/28 , A61P35/00 , G01N2500/00
摘要: The present disclosure relates to methods of extending the lifespan of a subject or treating, suppressing, inhibiting or delaying the onset of an age-related condition or disorder, such as cancer, in a subject. The methods comprise administering to the subject an effective amount of (i) a compound that sustains pharmacological activation of xenobiotic metabolism, (ii) a cardiac glycoside, (iii) a chelator, (iv) inulin, (v) D-valine, or any combination thereof. In a further aspect, the present disclosure relates to a method of identifying clinical candidates by performing a high throughput screening in mammals of test compounds which have great structural and/or functional diversity.
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