-
公开(公告)号：US10085936B2
公开(公告)日：2018-10-02
申请号：US13690647
申请日：2012-11-30
IPC分类号： A61K9/00 , A61K31/519 , A61K47/34
摘要： The present invention is directed to a composition that can be used to deliver an antipsychotic drug such as risperidone as an injectable in-situ forming biodegradable implant for extended release providing therapeutic plasma levels from the first day. The composition is in the form of drug suspension on a biodegradable and biocompatible copolymer or copolymers solution using water miscible solvents that is administered in liquid form. Once the composition contacts the body fluids, the polymer matrix hardens retaining the drug, forming a solid or semisolid implant that releases the drug in a continuous manner. Therapeutic plasma levels of the drug can be achieved since the first day up to at least 14 days or more even up to at least four weeks.
-
公开(公告)号：US20130171202A1
公开(公告)日：2013-07-04
申请号：US13690647
申请日：2012-11-30
IPC分类号： A61K9/00
CPC分类号： A61K9/0002 , A61K9/0024 , A61K31/519 , A61K47/34
摘要： The present invention is directed to a composition that can be used to deliver an antipsychotic drug such as risperidone as an injectable in-situ forming biodegradable implant for extended release providing therapeutic plasma levels from the first day. The composition is in the form of drug suspension on a biodegradable and biocompatible copolymer or copolymers solution using water miscible solvents that is administered in liquid form. Once the composition contacts the body fluids, the polymer matrix hardens retaining the drug, forming a solid or semisolid implant that releases the drug in a continuous manner. Therapeutic plasma levels of the drug can be achieved since the first day up to at least 14 days or more even up to at least four weeks.
摘要翻译： 本发明涉及一种组合物，其可用于递送抗精神病药物如利培酮作为可注射原位形成的可生物降解植入物，用于延长释放，从第一天起提供治疗性血浆水平。 该组合物是使用以液体形式施用的水混溶性溶剂在可生物降解和生物相容的共聚物或共聚物溶液中的药物悬浮液形式。 一旦组合物接触体液，聚合物基质就会硬化保留药物，形成以连续方式释放药物的固体或半固体植入物。 药物的治疗性血浆水平可以从第一天起达到至少14天甚至更多甚至至少四周。
-
公开(公告)号：US20230404906A1
公开(公告)日：2023-12-21
申请号：US18366400
申请日：2023-08-07
IPC分类号： A61K9/00 , A61K47/34 , A61K31/519
CPC分类号： A61K9/0002 , A61K47/34 , A61K31/519 , A61K9/0024
摘要： The present invention is directed to a composition that can be used to deliver an antipsychotic drug such as risperidone, paliperidone or a combination thereof, as an injectable in-situ forming biodegradable implant for extended release providing therapeutic plasma levels from the first day. The composition is in the form of drug suspension on a biodegradable and biocompatible copolymer or copolymers solution using water miscible solvents that is administered in liquid form. Once the composition contacts the body fluids, the polymer matrix hardens retaining the drug, forming a solid or semisolid implant that releases the drug in a continuous manner. Therapeutic plasma levels of the drug can be achieved from the first day up to at least 14 days or more even up to at least four weeks.
-
公开(公告)号：US11759416B2
公开(公告)日：2023-09-19
申请号：US17577170
申请日：2022-01-17
IPC分类号： A61K9/00 , A61K31/519 , A61K47/34
CPC分类号： A61K9/0002 , A61K9/0024 , A61K31/519 , A61K47/34
摘要： The present invention is directed to a composition that can be used to deliver an antipsychotic drug such as risperidone, paliperidone or a combination thereof, as an injectable in-situ forming biodegradable implant for extended release providing therapeutic plasma levels from the first day. The composition is in the form of drug suspension on a biodegradable and biocompatible copolymer or copolymers solution using water miscible solvents that is administered in liquid form. Once the composition contacts the body fluids, the polymer matrix hardens retaining the drug, forming a solid or semisolid implant that releases the drug in a continuous manner. Therapeutic plasma levels of the drug can be achieved from the first day up to at least 14 days or more even up to at least four weeks.
-
公开(公告)号：US20220112315A1
公开(公告)日：2022-04-14
申请号：US17509255
申请日：2021-10-25
摘要： Method for obtaining low molecular weight heparins (LMWH) with a weight average molecular weight distribution between 3.0 and 5.0 kDa comprising at least one concentration step by tangential flow filtration (TFF). The method is particularly useful for the preparation of bemiparin and enoxaparin without the use of fractional precipitation nor the use of alcoholic solutions. In particular, the preparation of LMWH is obtained by depolymerization of heparin and filtration (TFF ultrafiltration and/or diafiltration) of the depolymerized heparin without the use of fractional precipitation and without an alcoholic solution.
-
公开(公告)号：US11241377B2
公开(公告)日：2022-02-08
申请号：US16656167
申请日：2019-10-17
IPC分类号： A61K9/00 , A61K31/519 , A61K47/34
摘要： The present invention is directed to a composition that can be used to deliver an antipsychotic drug such as risperidone, paliperidone or a combination thereof, as an injectable in-situ forming biodegradable implant for extended release providing therapeutic plasma levels from the first day. The composition is in the form of drug suspension on a biodegradable and biocompatible copolymer or copolymers solution using water miscible solvents that is administered in liquid form. Once the composition contacts the body fluids, the polymer matrix hardens retaining the drug, forming a solid or semisolid implant that releases the drug in a continuous manner. Therapeutic plasma levels of the drug can be achieved from the first day up to at least 14 days or more even up to at least four weeks.
-
公开(公告)号：US20190231682A1
公开(公告)日：2019-08-01
申请号：US16294052
申请日：2019-03-06
IPC分类号： A61K9/00 , A61K31/4196 , A61K47/34
CPC分类号： A61K9/0024 , A61K31/4196 , A61K47/34
摘要： The present invention provides a composition suitable for forming an intramuscular implant. It comprises a biodegradable thermoplastic polymer of polylactic acid (PLA), DMSO and an aromatase inhibitor compound. The invention also provides a kit suitable for the in situ formation of the composition and its use as a medicine for treating cancer, especially breast cancer.
-
公开(公告)号：US08517557B2
公开(公告)日：2013-08-27
申请号：US13147756
申请日：2010-02-08
IPC分类号： F21V33/00
CPC分类号： A45D24/10 , A45D24/30 , A46B15/0034 , F21V33/0004 , F21V33/0064
摘要： A black light lice comb which can be easily held as it is being used to examine, clean and remove and/or eliminate nits, lice, eggs or nymphs on the scalp or from environments in which remains my be found wherein the comb is structured around a body including a battery compartment which is accessed at one end of the body and which is provided with a lamp device that contains diodes that emit black light and which is enclosed by means of a lens through which the light emitted by said diodes is projected, while one line or edge of the body contains a row of LEDs emitting black light corresponding to a guide from which a lice comb means is projected, formed by a plurality of teeth made from a material that conducts the black light emitted by the row of LEDs.
摘要翻译： 一种黑色的虱子梳子，可以容易地保持，因为它被用来检查，清洁和/或消除头皮上的虱子，虱子，鸡蛋或若虫，或者从我发现的那些环境中，梳子被围绕 包括电池仓的主体，其在身体的一端进入，并且设置有灯装置，该灯装置包含发射黑光的二极管，并且由透镜通过所述二极管发射的光投射的透镜包围， 而身体的一条线或边缘包含一排发出对应于虱子梳装置所引导的导光体的黑光的LED，该引线由导电由LED行发出的黑光的材料制成的多个齿形成 。
-
公开(公告)号：US20100316722A1
公开(公告)日：2010-12-16
申请号：US12779556
申请日：2010-05-13
IPC分类号： A61K9/14 , A61K31/727 , A61K31/702 , A61P7/02
CPC分类号： A61K9/1635 , A61K9/1647 , A61K9/5138 , A61K9/5153
摘要： Pharmaceutical form containing at least an active compound and a polymeric matrix, wherein said polymeric matrix comprises at least one polymer of cationic nature and at least one biodegradable polymer, process for the preparation thereof, pharmaceutical formulations comprising said pharmaceutical form, and their uses. The pharmaceutical form provides enhanced absorption of active compounds across the mucosa.
摘要翻译： 含有至少一种活性化合物和聚合物基质的药物形式，其中所述聚合物基质包含至少一种具有阳离子性质的聚合物和至少一种可生物降解聚合物，其制备方法，包含所述药物形式的药物制剂及其用途。 药物形式提供活性化合物在粘膜上的增强的吸收。
-
20.发明授权公开(公告)号：US07462735B2
公开(公告)日：2008-12-09
申请号：US10563994
申请日：2004-07-23
IPC分类号： C07C229/00 , A61K31/715 , A61K31/727 , A61K31/195
CPC分类号： C07C237/42
摘要： Amino acid diamides in non α position of formula (1), wherein R1 is selected from amongst the group consisting of the functional groups alkyl, halogen, NO2, OH, OCH3 alone or associated and R2 is selected from the group consisting of functional groups H, alkyl, halogen, NO2, OH, OCH3, which are useful as adjuvants for the administration of biological active agents, as well as pharmaceutical compositions containing these diamides of formula (1) and the use thereof for the manufacture of antithrombotic medications and for the manufacture of a medication for the treatment of a disease selected from amongst the group consisting of inflammation, cancer and allergy.
摘要翻译： 式（1）的非α位的氨基酸二酰胺，其中R 1选自单独或相连的官能团烷基，卤素，NO 2，OH，OCH 3，R 2选自官能团H ，烷基，卤素，NO 2，OH，OCH 3，其可用作用于生物活性剂的给药的佐剂，以及含有这些式（1）的二酰胺的药物组合物及其用于制备抗血栓药物的用途， 制造用于治疗选自炎症，癌症和过敏的疾病的药物。
-
-
-
-
-
-
-
-
-
搜索结果
42 条记录 (耗时 0.032 秒)
