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    METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE
    13.
    发明申请
    METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE 有权

    公开(公告)号：US20210010068A1

    公开(公告)日：2021-01-14

    申请号：US16986922

    申请日：2020-08-06

    Applicant: Prognosys Biosciences, Inc.

    Inventor： Mark S. CHEE ,  David A. ROUTENBERG

    IPC: C12Q1/6809

    Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.

    Polynucleotide conjugates and methods for analyte detection
    18.
    发明授权
    Polynucleotide conjugates and methods for analyte detection 有权

    公开(公告)号：US10288608B2

    公开(公告)日：2019-05-14

    申请号：US15035206

    申请日：2014-11-07

    Applicant: Prognosys Biosciences, Inc.

    Inventor： Igor A. Kozlov ,  John Andrew Altin ,  Petr Capek ,  Mark S. Chee

    IPC: C12Q1/6804 ,  G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  C12Q1/6816 ,  C12Q1/689

    Abstract: The present disclosure provides polynucleotide conjugates, methods, and assay systems for use in detecting the presence, absence, and/or amount of an analyte in a sample. Various polynucleotide conjugates, conjugate pairs, sets, libraries, and assay systems comprising the same are disclosed. In particular, methods and assay systems for antibody detection and analysis are provided. For example, assays capable of high levels of multiplexing are used for antibody detection and analysis in a biological sample, e.g., Lyme disease patient samples. The presently disclosed polynucleotide conjugates, methods, and assay systems can be used to provide sensitive and reliable diagnosis, even at early stages of a disease or condition. Use for monitoring disease progression and prognosis is also disclosed.

    Spatially encoded biological assays using a microfluidic device
    20.
    发明授权
    Spatially encoded biological assays using a microfluidic device 有权

    公开(公告)号：US09868979B2

    公开(公告)日：2018-01-16

    申请号：US14900602

    申请日：2014-06-25

    Applicant: Prognosys Biosciences, Inc.

    Inventor： Mark S. Chee ,  David A. Routenberg

    IPC: C12Q1/68 ,  B01L3/00

    CPC classification number: C12Q1/6809 ,  B01L3/5027 ,  C12Q2565/513 ,  C12Q2565/629

    Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents, in particular, microfluidic device based instrumentation; and a decoding scheme providing a readout that is digital in nature.

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