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    MICROFLUIDIC INDUCTION OF RESEARCH BASED NEURAL INJURY
    4.
    发明公开
    MICROFLUIDIC INDUCTION OF RESEARCH BASED NEURAL INJURY 审中-公开

    公开(公告)号：US20240326041A1

    公开(公告)日：2024-10-03

    申请号：US18621550

    申请日：2024-03-29

    申请人： Worcester Polytechnic Institute

    发明人： Hamilton A. White ,  Dirk R. Albrecht

    IPC分类号： B01L3/00

    CPC分类号： B01L3/5027

    摘要： A microfluidic device for evaluation of test subjects for induced neural injury performs testing of multiple test subjects based on uniform and repeatable test stimuli for evaluating neural response for research including traumatic brain injury. A microfluidic device contains multiple test subjects and delivers a consistent, measured test stimuli simulating TBI to each of the test subjects simultaneously. The result is a system to assess neural function, behavior, and neural structure of small animals responsive to sonication-induced traumatic brain injury, to investigate risk and potential recovery. The microfluidic device disposes test subjects at a uniform distance from an injury inducing surface that emits sonication energy to simulate TBI. The uniform distance ensures that each test subject receives the same, controlled injury stimuli, and the test subjects may be evaluated with an attached microscope or video input, or may be extracted from the microfluidic device for further evaluation.

    ORGANS-ON-CHIPS AS A PLATFORM FOR EPIGENETICS DISCOVERY
    6.
    发明公开
    ORGANS-ON-CHIPS AS A PLATFORM FOR EPIGENETICS DISCOVERY 审中-公开

    公开(公告)号：US20240299932A1

    公开(公告)日：2024-09-12

    申请号：US18659536

    申请日：2024-05-09

    申请人： EMULATE, INC.

    发明人： Catherine Karalis ,  Ville Kujala

    IPC分类号： B01L3/00 ,  C12M1/12 ,  C12M3/06 ,  C12Q1/6809 ,  G01N33/50

    CPC分类号： B01L3/5027 ,  C12M23/16 ,  C12Q1/6809 ,  G01N33/5023 ,  G01N33/5064 ,  G01N33/5091 ,  B01L2300/0819 ,  B01L2400/0487 ,  C12M25/02

    摘要： The present invention relates to microfluidic fluidic devices, methods and systems for use in identifying epigenetic signatures in a range of sample types, e.g., cells established on a “chip” (including but not limited to single cell samples, cell populations, cell layers and whole tissues, such as a biopsy), immune cells, cfDNA, exosomes, and the like. More specifically, in some embodiments, a microfluidic chip containing a sample is contacted with a test compound (e.g. DNA altering test compound, an RNA expression altering test compound, etc.) for use in providing a diagnostic epigenetic signature for that type of sample (or cell type) exposed to that specific test compound. In some embodiments, after contact with a test compound, effluent fluids (e.g. fluids exiting the “chip” that contacted the cells) are derived for testing as a “virtual blood draw.” In some embodiments, epigenetic signatures include (but are not limited to) identifying specific combinations of modifications of chromosomes and specific modifications of DNA.