公开(公告)号：US20210253721A1

公开(公告)日：2021-08-19

申请号：US17160096

申请日：2021-01-27

Applicant: UNIVERSITY OF SOUTH AUSTRALIA ,  CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC

Inventor： Angel F. Lopez ,  Claudine S. Bonder ,  Emma Thompson

IPC: C07K16/28 ,  G01N33/574 ,  A61P35/04 ,  C07K16/24

Abstract: A method of treating or preventing breast cancer (eg invasive ductal carcinoma) and/or cancer associated with elevated levels of either one or both of the IL-3 receptor (IL-3R) and interleukin-3 (IL-3) is disclosed which comprises administering to a subject an IL-3-inhibiting agent such as an agent which inhibits (eg by blocking) IL-3R.

公开(公告)号：US10583115B2

公开(公告)日：2020-03-10

申请号：US15517755

申请日：2015-10-08

Applicant: University of South Australia ,  Central Adelaide Local Health Network Inc.

Inventor： Joanna Woodcock ,  Angel Lopez ,  Stuart Maxwell Pitson ,  Michael Susithiran Samuel ,  Carl Coolen

IPC: A61K31/395 ,  A61K45/06 ,  A61K31/40 ,  A61K31/452 ,  A61K9/00 ,  A61K47/10 ,  A61K9/06

Abstract: The present disclosure relates to modulators of 14-3-3 functionality and their use in methods and compositions for preventing and/or treating various diseases, conditions and states, such as cancer and healing of wounds. Certain embodiments of the present disclosure provide a method of preventing and/or treating a disease, condition or state in a subject associated with altered 14-3-3 protein functionality and/or which would benefit from altering 14-3-3 functionality, the method comprising administering to the subject an effective amount of an agent which inhibits dimerization of the 14-3-3 protein, thereby preventing and/or treating the disease, condition or state in the subject.