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    NANOPARTICLE CANCER THERAPY
    6.
    发明公开
    NANOPARTICLE CANCER THERAPY 审中-公开

    公开(公告)号：US20230414528A1

    公开(公告)日：2023-12-28

    申请号：US18240743

    申请日：2023-08-31

    申请人： UNIVERSITY OF SOUTH AUSTRALIA

    发明人： Ivan Mark KEMPSON ,  Tyron James TURNBULL

    IPC分类号： A61K9/51 ,  A61P35/00 ,  A61K33/242 ,  A61K41/00

    CPC分类号： A61K9/5123 ,  A61P35/00 ,  B82Y5/00 ,  A61K41/0038 ,  A61K33/242

    摘要： Methods of potentiating chemotherapy or radiotherapy are disclosed. The methods comprise administering to a subject in need of chemotherapeutic or radiotherapeutic treatment an effective amount of a composition comprising biocompatible nanoparticles under conditions in which the nanoparticles alter one or more cell regulatory mechanisms in cells in which the nanoparticles are localised or other cells. Then one or more doses of a chemotherapeutic or radiotherapeutic treatment are administered to the subject either concurrently with or after the nanoparticles have altered the one or more cell regulatory mechanisms in the cells in which the nanoparticles are localised or other cells. Also disclosed are methods of enhancing the effects of chemotherapy or radiotherapy on a cell population, methods of increasing the amount of strand breaks in DNA in a cell, and methods of inducing cancer cell death.

    Pumpless Microfluidic Devices and Uses Thereof
    8.
    发明申请
    Pumpless Microfluidic Devices and Uses Thereof 有权

    公开(公告)号：US20220372418A1

    公开(公告)日：2022-11-24

    申请号：US17774078

    申请日：2020-11-04

    申请人： University of South Australia

    发明人： Craig Ian Priest ,  Edward Cheah ,  Ludivine Delon ,  Azadeh Nilghaz ,  Benjamin Thierry

    IPC分类号： C12M3/06 ,  C12M1/34

    摘要： Provided is an apparatus for inducing and/or controlling flow of a fluid within a microchannel in a microfluidic device. The apparatus includes a fluid reservoir configured for holding a volume of fluid to be transported through said microfluidic channel and also configured for fluid connection to an inlet of said microfluidic channel. The apparatus also includes an evaporation reservoir configured for fluid connection to an outlet of said microfluidic channel. The evaporation reservoir includes at least one wetting, wicking or hydrophilic structure positioned at least partly within the reservoir. The wetting, wicking, or hydrophilic structure is capable of absorbing or conducting a fluid present in the microfluidic channel via wicking action or capillary force and maintaining a substantially constant volume of fluid in the evaporation reservoir. In use, evaporation of fluid at the outlet results in fluid being drawn from the fluid reservoir through the microfluidic channel to thereby create a flow of the fluid in the microfluidic channel.